Rabbit Anti-PAFAH1B1 Recombinant Antibody (clone R03-2I0)
CAT#: VS3-FY1760
The R03-2I0 is a rabbit recombinant monoclonal antibody that with high affinity for human PAFAH1B1. It cross-reacts with hamster, rat. The R03-2I0 is recommended for dilution of target protein by western blot (dilution 1/500-1/1000), immunoprecipitation (dilution 1/20).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to centrosome.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20036/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20036/45863_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20036/45863_A_8_3.jpg
Normal Tissue
Figure 4 Pancreas
Exocrine glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Pancreatic endocrine cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20036/45863_A_3_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20036/45863_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20036/45863_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20036/45863_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000007168-PAFAH1B1
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Specifications
- Immunogen
- Synthetic peptide of human LIS1
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Hamster, Rat PAFAH1B1
- Species Reactivity
- Human, Hamster, Rat
- Clone
- R03-2I0
- Applications
- Western Blot, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 47 kDa, while the observed molecular weight stands at 47 kDa.
- Related Disease
- Lissencephaly 1 and Miller-Dieker Lissencephaly Syndrome
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunoprecipitation: 1/20
Target
- Alternative Names
- Platelet Activating Factor Acetylhydrolase 1b Regulatory Subunit 1; Platelet-Activating Factor Acetylhydrolase, Isoform Ib, Alpha Subunit (45kD); Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa); Platelet-Activating Factor Acetylhydrolase, Isoform Ib, Subunit 1 (45kDa); MDCR; LIS1; MDS; Platelet-Activating Factor Acetylhydrolase, Isoform Ib, Alpha Subunit 45kDa; Platelet-Activating Factor Acetylhydrolase IB Subunit Alpha; Miller-Dieker Syndrome Chromosome Region; PAF Acetylhydrolase 45 KDa Subunit; Lissencephaly 1 Protein
- Gene ID
- 5048
- UniProt ID
- P43034
- Sequence Similarities
- Belongs to the WD repeat LIS1/nudF family.
- Cellular Localization
- Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus
- Post Translation Modifications
- Acetylation
Phosphoprotein
- Protein Refseq
- XP_011522203.1; XP_011522204.1; XP_011522205.1; XP_016880190.1; XP_016880192.1
- Function
- Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "PAFAH1B1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2576 | Hi-Affi™ Recombinant Rabbit Anti-PAFAH1B1 Monoclonal Antibody (DS2576AB) | WB, IP, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC866 | Rabbit Anti-PAFAH1B1 Recombinant Antibody (VS13-YC866) | WB, IP | Rabbit IgG |
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