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  • Rabbit Anti-PAFAH1B1 Recombinant Antibody (clone R03-2I0)

Rabbit Anti-PAFAH1B1 Recombinant Antibody (clone R03-2I0) (CAT#: VS3-FY1760)

The R03-2I0 is a rabbit recombinant monoclonal antibody that with high affinity for human PAFAH1B1. It cross-reacts with hamster, rat. The R03-2I0 is recommended for dilution of target protein by western blot (dilution 1/500-1/1000), immunoprecipitation (dilution 1/20).


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Specific Inquiry
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Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to centrosome.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20036/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20036/45863_B_9_5.jpg
Figure 3 Colon
Figure 3 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20036/45863_A_8_3.jpg
Figure 4 Pancreas
Figure 4 Pancreas
(Exocrine glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Pancreatic endocrine cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20036/45863_A_3_3.jpg
Figure 5 Kidney
Figure 5 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20036/45863_A_7_5.jpg
Figure 6 Testis
Figure 6 Testis
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20036/45863_A_6_6.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20036/45863_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000007168-PAFAH1B1

Specifications

  • Immunogen
  • Synthetic peptide of human LIS1
  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human, Hamster, Rat PAFAH1B1
  • Species Reactivity
  • Human, Hamster, Rat
  • Clone
  • R03-2I0
  • Applications
  • Western Blot, Immunoprecipitation
  • MW
  • The calculated weight of the target protein is approximately 47 kDa, while the observed molecular weight stands at 47 kDa.
  • Related Disease
  • Lissencephaly 1 and Miller-Dieker Lissencephaly Syndrome

Product Property

  • Purification
  • Affinity Purified
  • Format
  • Liquid
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • Western Blot: 1/500-1/1000
    Immunoprecipitation: 1/20

Target

  • Alternative Names
  • Platelet Activating Factor Acetylhydrolase 1b Regulatory Subunit 1; Platelet-Activating Factor Acetylhydrolase, Isoform Ib, Alpha Subunit (45kD); Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa); Platelet-Activating Factor Acetylhydrolase, Isoform Ib, Subunit 1 (45kDa); MDCR; LIS1; MDS; Platelet-Activating Factor Acetylhydrolase, Isoform Ib, Alpha Subunit 45kDa; Platelet-Activating Factor Acetylhydrolase IB Subunit Alpha; Miller-Dieker Syndrome Chromosome Region; PAF Acetylhydrolase 45 KDa Subunit; Lissencephaly 1 Protein
  • Sequence Similarities
  • Belongs to the WD repeat LIS1/nudF family.
  • Cellular Localization
  • Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus
  • Post Translation Modifications
  • Acetylation
    Phosphoprotein
  • Function
  • Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates.

Recommended Products

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "PAFAH1B1"

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2576 Hi-Affi™ Recombinant Rabbit Anti-PAFAH1B1 Monoclonal Antibody (DS2576AB) WB, IP, FC IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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