Rabbit Anti-PAFAH1B1 Recombinant Antibody (VS13-YC866) (CAT#: VS13-YC866)

• Immunogen
• Recombinant human LIS1.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Hamster and Rat PAFAH1B1

• Species Reactivity
• Human, Hamster, Rat

• Applications
• WB, IP

• Conjugate
• NONE

• Related Disease
• Lissencephaly and Miller-Dieker Lissencephaly Syndrome

• Clonality
• Monoclonal

• Purification
• Affinity Chromatography purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.

• Preservative
• 0.01% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Western blot (WB): 1/500-1/1000
  Immunoprecipitation (IP): 1/20

• Alternative Names
• Platelet Activating Factor Acetylhydrolase 1b Regulatory Subunit 1; Platelet-Activating Factor Acetylhydrolase, Isoform Ib, Alpha Subunit (45kD); Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa); Platelet-Activating Factor Acetylhydrolase, Isoform Ib, Subunit 1 (45kDa); MDCR; LIS1; MDS; Platelet-Activating Factor Acetylhydrolase, Isoform Ib, Alpha Subunit 45kDa; Platelet-Activating Factor Acetylhydrolase IB Subunit Alpha; Miller-Dieker Syndrome Chromosome Region; PAF Acetylhydrolase 45 KDa Subunit; Lissencephaly 1 Protein;

• Gene ID
• 5048

• UniProt ID
• P43034

• Long Name
• Platelet Activating Factor Acetylhydrolase 1b Regulatory Subunit 1

• Sequence Similarities
• Belongs to the WD repeat LIS1/nudF family.

• Cellular Localization
• Cytoplasm; Cytoskeleton; Membrane; Microtubule; Nucleus

• Protein Refseq
• XP_011522203.1; XP_011522204.1; XP_011522205.1; XP_016880190.1; XP_016880192.1

• Function
• Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates.

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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