Rabbit Anti-PAH Recombinant Antibody (clone R06-3H4)
CAT#: VS3-FY1613
The R06-3H4 recombinant monoclonal antibody with high affinity for human PAH. It cross-reacts with mouse, rat. The binding specificity of the PAH antibody was determined using western blot analysis of PAH in 3T3, C6, rat brain, K562 lysates.
Gene Expression
Tested Data
Subcellular Location
Figure 1 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28407/1399_C5_1_selected.jpg
Normal Tissue
Figure 2 High expression in liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31642/150831_A_9_4.jpg
Normal Tissue
Figure 3 Gallbladder
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31642/150831_A_5_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31642/150831_A_7_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000171759-PAH
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WB
Figure 1 Anti-PAH Antibody (VS3-FY1613) in WB.
The PAH expression in 3T3, C6, rat Brain, K562 lysates were detected using the anti-PAH by western blot assay.
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Specifications
- Immunogen
- Synthetic peptides of human PAH
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat PAH
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R06-3H4
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 52 kDa, while the observed molecular weight stands at 52 kDa.
- Related Disease
- Phenylketonuria and Hyperphenylalaninemia.
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Phenylalanine Hydroxylase; Phenylalanine 4-Monooxygenase; Phe-4-Monooxygenase; EC 1.14.16.1; Phenylalanine-4-Hydroxylase; EC 1.14.16; PKU1; PKU; PH
- Gene ID
- 5053
- UniProt ID
- P00439
- Sequence Similarities
- Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
- Cellular Localization
- Cytosol
- Post Translation Modifications
- Phosphorylation at Ser-16 increases basal activity and facilitates activation by the substrate phenylalanine.
- Protein Refseq
- NP_000268.1
- Function
- Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "PAH"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1959z | Mouse Anti-PAH Recombinant Antibody (clone 36C11) | WB, ELISA, IF, IHC, IP | Mouse IgG1, κ |
| VS3-QX848 | Mouse Anti-PAH Recombinant Antibody (clone 717CT21.1.1) | WB, IHC | Mouse IgG1, κ |
| VS3-CJ204 | Mouse Anti-PAH Recombinant Antibody (VS3-CJ204) | WB, IHC-P | Mouse IgG1, κ |
| VS4-CJ66 | Recombinant Rabbit Anti-PAH Antibody (clone 17D10) | ELISA, IHC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2580 | Hi-Affi™ Recombinant Rabbit Anti-PAH Monoclonal Antibody (DS2580AB) | WB, IHC-P, ICC, IF, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5160 | Anti-PAH Immunohistochemistry Kit | IHC | |
| VS-0525-XY5161 | Anti-Mouse PAH Immunohistochemistry Kit | IHC | |
| VS-0525-XY5162 | Anti-Rat PAH Immunohistochemistry Kit | IHC |
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