Rabbit Anti-PAWR Recombinant Antibody (clone R01-8C0) (CAT#: VS3-FY2058)
The R01-8C0 recombinant monoclonal antibody with high affinity for human PAWR. It cross-reacts with mouse. It is suitable for use in a variety of assays, including WB, IP. The antibody has the positive detection of PAR4 protein by western blot analysis of PAR4 in 3T3 lysates.
Specific Inquiry
WB
Figure 1 Anti-PAWR Antibody (VS3-FY2058) in WB.
The PAR4 expression in 3T3 lysates were detected using the anti-PAR4 by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human PAR4
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse PAWR
- Species Reactivity
- Human, Mouse
- Clone
- R01-8C0
- Applications
- Western Blot, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 37 kDa, while the observed molecular weight stands at 41 kDa.
- Related Disease
- Cancer
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunoprecipitation: 1/20
Target
- Alternative Names
- Pro-Apoptotic WT1 Regulator; PRKC, Apoptosis, WT1, Regulator; Prostate Apoptosis Response-4; PAR-4; PAR4; Prostate Apoptosis Response Protein PAR-4
- Gene ID
- 5074
- UniProt ID
- Q96IZ0
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Preferentially phosphorylated at the Thr-163 by PKC in cancer cells. (Q96IZ0-PAWR_HUMAN)
Ubiquitination at Lys333 (NX_Q96IZ0 [NX_Q96IZ0-1])
Modification sites at PhosphoSitePlus (Q96IZ0)
Glycosylation from GlyGen (Q96IZ0) 12 sites, 1 O-linked glycan (12 sites)
- Protein Refseq
- XP_016874867.1; XP_016874868.1; XP_047284872.1; XP_047284873.1; XP_047284874.1
- Function
- Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "PAWR"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1548CT | Recombinant Mouse anti-Human PAWR Monoclonal antibody (4H0I8,5I23F0) | ELISA, IHC-P, WB | |
| ZG-0354C | Mouse Anti-PAWR Recombinant Antibody (ZG-0354C) | WB, IHC, ELISA | Mouse IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2599 | Hi-Affi™ Recombinant Rabbit Anti-PAWR Monoclonal Antibody (DS2599AB) | IP, WB | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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