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    Mouse Anti-PAWR Monoclonal Antibody (VS7-0425-WR563) (CAT#: VS7-0425-WR563)

    This product is a mouse IgG antibody that binds to human PAWR. The antibody recognizes specific amino acid domain of PAR4 (aa1-330). It can be used for WB, IHC-P, IF, and ELISA assays.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line SiHa
    Figure 1 IF staining of human cell line SiHa
    (Immunofluorescent staining of human cell line SiHa shows localization to plasma membrane & actin filaments.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/12640/1183_B9_2_selected.jpg
    Figure 2 IF staining of human cell line A-431
    Figure 2 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & actin filaments.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/20779/if_selected.jpg
    Normal Tissue
    Figure 3 Lymph node
    Figure 3 Lymph node
    (Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/12640/31196_A_9_8.jpg
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/12640/31196_B_7_5.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/12640/31196_A_7_3.jpg
    Figure 6 Liver
    Figure 6 Liver
    (Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/12640/31196_A_7_4.jpg
    Figure 7 Kidney
    Figure 7 Kidney
    (Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/12640/31196_A_9_5.jpg
    Figure 8 Testis
    Figure 8 Testis
    (Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/12640/31196_A_5_6.jpg
    RNA Expression
    Figure 9 RNA cell line category: Low cell line specificity
    Figure 9 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000177425-PAWR

    Specifications

    • Immunogen
    • Recombinant PAR4 (aa1-330) fragment expressed in E. Coli.
    • Host Species
    • Mouse
    • Type
    • Mouse IgG
    • Specificity
    • Human PAWR
    • Species Reactivity
    • Human
    • Molecule Class
    • G-Protein-Coupled Receptors (GPCRs)
    • Applications
    • WB, IHC-P, IF, ELISA
    • Conjugate
    • Unconjugated

    Product Property

    • Clonality
    • Monoclonal
    • Purity
    • >95% as determined by SDS-PAGE and SEC-HPLC analysis, Ascitic fluid
    • Format
    • Liquid
    • Concentration
    • 1 mg/ml
    • Preservative
    • 0.03% sodium azide
    • Storage
    • Centrifuge briefly prior to opening vial. Aliquot and store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • Western Blot: 1:500 - 1:2000
      Immunohistochemistry: 1:200 - 1:1000
      Enzyme-linked Immunosorbent Assay: 1:10000

    Target

    • Alternative Names
    • PAR4; Par-4
    • Long Name
    • Pro-Apoptotic WT1 Regulator
    • Cellular Localization
    • Cytoplasm; Nucleus
    • Post Translation Modifications
    • Phosphoprotein
    • Function
    • Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

    Recommended Products

    Isotype Control

    Secondary Antibody

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "PAWR"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    IgG Antibodies Rabbit Monoclonal Antibodies IHC Kits & Antibodies
    CAT Product Name Application Type
    MOB-1548CT Recombinant Mouse anti-Human PAWR Monoclonal antibody (4H0I8,5I23F0) ELISA, IHC-P, WB
    ZG-0354C Mouse Anti-PAWR Recombinant Antibody (ZG-0354C) WB, IHC, ELISA Mouse IgG
    VS3-FY2058 Rabbit Anti-PAWR Recombinant Antibody (clone R01-8C0) WB, IP Rabbit IgG
    VS13-YC870 Rabbit Anti-PAWR Recombinant Antibody (VS13-YC870) WB Rabbit IgG
    VS7-0425-WR559 Mouse Anti-PAWR Monoclonal Antibody (clone 3G9H7) WB, IHC Mouse IgG1

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