Rabbit Anti-PICK1 Recombinant Antibody (clone R01-4D1) (CAT#: VS3-FY1832)

• Immunogen
• Synthetic peptide of human PICK1

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human PICK1

• Species Reactivity
• Human

• Clone
• R01-4D1

• Applications
• Western Blot, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 47 kDa, while the observed molecular weight stands at 50 kDa.

• Related Disease
• Spermatogenic Failure 9 and Spermatogenic Failure 5

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunoprecipitation: 1/20

• Alternative Names
• Protein Interacting With PRKCA 1; Protein Kinase C-Alpha-Binding Protein; Protein Interacting With C Kinase 1; PRKCABP; Protein Kinase C, Alpha Binding Protein; Protein Interacting With PRKCA; PRKCA-Binding Protein; PICK

• Gene ID
• 9463

• UniProt ID
• Q9NRD5

• Cellular Localization
• Cytoplasm, Cytoskeleton, Membrane, Synapse, Synaptosome

• Post Translation Modifications
• Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors. (Q9NRD5-PICK1_HUMAN)
  Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD). (Q9NRD5-PICK1_HUMAN)
  Ubiquitination at Lys209 (NX_Q9NRD5 [NX_Q9NRD5-1])
  Modification sites at PhosphoSitePlus (Q9NRD5)

• Protein Refseq
• XP_011528819.1; XP_047297565.1; XP_047297566.1; XP_047297567.1; XP_047297568.1

• Function
• Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

Select a product category from the dropdown menu below to view related products.