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PICK1
Loading...Anti-PICK1 Products
- Mouse Anti-PICK1 Recombinant Antibody (VS-0522-LC9) (VS-0522-LC9)
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- Species Reactivity: Rat, Human, Mouse
- Type: Mouse IgG2a
- Application: IB, IHC, IP
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- Rat Anti-PICK1 Recombinant Antibody (VS-0522-LC10) (VS-0522-LC10)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rat IgG2b
- Application: IB, IHC, IP
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- Human Anti-PICK1 Recombinant Antibody (VS-0522-LC11) (VS-0522-LC11)
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- Species Reactivity: Rat, Human, Mouse
- Type: Human IgG1
- Application: IB, IHC, IP
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- Rabbit Anti-PICK1 Recombinant Antibody (VS-0522-LC12) (VS-0522-LC12)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rabbit IgG
- Application: IB, IHC, IP
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ELISA
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- Chicken Anti-PICK1 Polyclonal IgY (BRD-0795MZ)
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- Species Reactivity: Mouse, Rat
- Type: Chicken antibody
- Application: ICC, IF, IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids, Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR. Interacts with UNC5A. Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner. Interacts with F-actin and associates with the ARP2/3 complex. Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition.
Molecular function
Actin-binding
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