Human Anti-PIV3 Prefusion Recombinant Antibody Fab Fragment (PABJ-0161-F(E))

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Citations

1. Marcink, Tara C., et al. "Subnanometer structure of an enveloped virus fusion complex on viral surface reveals new entry mechanisms." Science Advances 9.6 (2023): eade2727. https://doi.org/10.1126/sciadv.ade2727
   The study aims to investigate the structure of the fusion complex of human parainfluenza virus 3 (HPIV3) using cryo-electron tomography. It specifically focuses on the interaction between the hemagglutinin-neuraminidase (HN) and fusion (F) proteins, which are essential for viral entry into host cells. By visualizing these proteins at subnanometer resolution, the researchers were able to detail how HN and F proteins remain in a quiescent state on the viral surface until activation and how HN facilitates F's role in the fusion process. This research provides insights into the mechanisms of viral entry and potential targets for antiviral therapies.
   Creative Biolabs contributed to this research by supplying the PIA174 antibody Fab fragment (Cat# PABJ-0161-F(E)) and full antibody (Cat# PABJ-0161) used in the study. The catalog number for these products is not explicitly mentioned in the document. These antibodies were crucial for structural studies, allowing the researchers to stabilize and visualize the prefusion F complex and understand the precise interaction between HN and F proteins. The use of these antibodies facilitated the detailed examination of the viral fusion mechanism, which is essential for developing strategies to prevent viral entry into host cells.

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(Creative Biolabs Cat# PABJ-0161-F(E), RRID: AB_3111611)

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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