Mouse Anti-PKHD1 Recombinant Antibody (clone 8G12A1) (CAT#: VS7-0425-WR620)

• Immunogen
• Recombinant mouse PKHD1 (AA: 3878-4060) fragment expressed in E. Coli.

• Host Species
• Rat

• Type
• Rat IgG1

• Specificity
• Human PKHD1

• Species Reactivity
• Human

• Clone
• 8G12A1

• Molecule Class
• Transmembrane Protein

• Applications
• IHC, ICC, FC

• Conjugate
• Unconjugated

• Clonality
• Monoclonal

• Purity
• >95% as determined by SDS-PAGE and SEC-HPLC analysis

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• 0.05% sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Immunohistochemistry-Paraffin: 1:200 - 1:1000
  Immunocytochemistry: 1:200 - 1:1000
  Flow Cytometry: 1:200 - 1:400
  Enzyme-linked Immunosorbent Assay: 1:10000

• Alternative Names
• FPC; Tigm1

• Gene ID
• 241035

• UniProt ID
• E9PZ36

• Long Name
• PKHD1 ciliary IPT domain containing fibrocystin/polyductin

• Cellular Localization
• Cell membrane; Cell projection; Centromere; Chromosome; Cytoplasm; Cytoskeleton; Endoplasmic reticulum; Golgi apparatus; Membrane; Nucleus; Secreted

• Post Translation Modifications
• Glycoprotein

• Protein Refseq
• NP_694819.2

• Function
• Promotes ciliogenesis in renal epithelial cells and therefore participates in the tubules formation and/or ensures the maintenance of the architecture of the lumen of the kidney (PubMed:18235088, PubMed:20875407).; Has an impact on cellular symmetry by ensuring correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly and by maintaining oriented cell division (OCD) during tubular elongation through planar cell polarity (PCP) pathway (PubMed:19959710).; During epithelial cell morphogenesis regulates also cell-cell and cell-matrix adhesion and participates in cell motility (By similarity).; Promotes cell-cell contact through the positive regulation of PTK2 kinase activity leading to either positive regulation of epithelial cell proliferation through the HRAS/RAF1 pathways, or negative regulation of apoptosis through the PDK1/AKT1 pathway (PubMed:20875407).; May act in collecting-duct and biliary differentiation (By similarity).; May participate in the regulation of the cholangiocytes proliferation and the CCN2 production in an CXCL8-dependent manner (By similarity).

Isotype Control

• MOB-209CQ
• Rat IgG1, kappa Isotype Control Antibody

• MOB-210CQ
• Rat IgG1, lambda Isotype Control Antibody

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