Anti-PKM (clone W24V253) Recombinant Antibody Coupled Liposome (VS-1024-FY250)
CAT#: VS-1024-FY250
Anti-PKM2 antibody conjugated liposomes hold significant potential in targeting subcutaneous F9 teratocarcinoma tumors by enhancing the delivery of therapeutic agents specifically to cancer cells expressing the PKM2 enzyme. This targeted approach can improve the efficacy of treatments while minimizing off-target effects, leading to better therapeutic outcomes. Additionally, the use of liposomes as delivery vehicles allows for controlled release and improved bioavailability of the encapsulated drugs. Ultimately, this strategy could result in novel and effective treatment modalities for teratocarcinoma and similar malignancies.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29501/283_B10_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19421/if_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human fallopian tube
Immunohistochemical staining of human fallopian tube shows moderate cytoplasmic and membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29501/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows strong cytoplasmic positivity in urothelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19421/ihc_selected.jpg
Normal Tissue
Figure 5 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29501/60955_B_8_5.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29501/60955_A_9_3.jpg
Normal Tissue
Figure 7 Liver
Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29501/60955_A_9_4.jpg
Normal Tissue
Figure 8 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29501/60955_A_9_5.jpg
Normal Tissue
Figure 9 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29501/60955_A_4_6.jpg
Normal Tissue
Figure 10 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29501/60955_A_8_8.jpg
RNA Expression
Figure 11 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000067225-PKM
❮
❯
More Infomation
Specifications
- Potential Clinical Applications
- Subcutanous F9 teratocarcinoma tumours
Product Composition
- Clone
- W24V253
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This recombinant mouse monoclonal antibody was specifically engineered to recognize and bind to the PKM2 protein, which plays a critical role in cellular metabolism and energy regulation. By targeting PKM2, this antibody can potentially be used in various research and therapeutic applications, including cancer studies, where PKM2 is often implicated in tumor growth and metabolism. The ability to selectively bind to PKM2 makes this antibody a valuable tool for scientists seeking to understand its function and involvement in various biological processes.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- PKM
- Introduction
- This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate.
- Alternative Names
- PK3; TCB; OIP3; PKM2; CTHBP; THBP1; HEL-S-30
- Full Name
- pyruvate kinase M1/2
- Gene ID
- 5315
- UniProt ID
- P14618
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- ISGylated. (P14618-KPYM_HUMAN)
Under hypoxia, hydroxylated by EGLN3. (P14618-KPYM_HUMAN)
Acetylation at Lys-305 is stimulated by high glucose concentration, it decreases enzyme activity and promotes its lysosomal-dependent degradation via chaperone-mediated autophagy.
- Protein Refseq
- XP_005254502.1; XP_005254500.1
- Function
- Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:20847263, 15996096, 1854723).
The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:20847263, 15996096, 1854723).
The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1024-FY250. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "PKM"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2125-CN | Rabbit Anti-PKM Polyclonal Antibody (MRO-2125-CN) | WB, IF, IHC | Rabbit IgG |
| ZG-0247U | Mouse Anti-PKM Recombinant Antibody (clone 6C3C7) | ELISA, WB, IHC, IF, FC, IP | Mouse IgG1 |
| ZG-0248U | Mouse Anti-PKM Recombinant Antibody (clone 4C8E12) | ELISA, WB, IHC, IF, FC, IP | Mouse IgG1 |
| ZG-0513U | Rabbit Anti-PKM Recombinant Antibody (clone 7B2) | ELISA, WB, IHC, IF, FC, IP | Rabbit IgG |
| VS3-CJ43 | Mouse Anti-PKM Recombinant Antibody (VS3-CJ43) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY393 | Rabbit Anti-NHP PKM Recombinant Antibody (VS-1024-XY393) | WB, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY178 | CytoStream™ Rabbit Anti-PKM Recombinant Antibody (VS-0225-XY178) | FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5443 | Anti-PKM Immunohistochemistry Kit | IHC | |
| VS-0525-XY5444 | Anti-Rat PKM Immunohistochemistry Kit | IHC | |
| VS-0525-XY5445 | Anti-Mouse PKM Immunohistochemistry Kit | IHC |
See Our Custom Production in Action
Popular Products
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: WB, IHC, FC, Cyt, ELISA
Application: Neut, ELISA, FuncS
Application: WB, ELISA, FuncS
Application: WB, ELISA, FC, IHC, IP
Application: IF, IP, Neut, FuncS, ELISA, FC
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
