Mouse Anti-PORCN Recombinant Antibody (clone VS0724W6) (CAT#: VS-0724-FY24)
This is a monoclonal antibody, called VS0724W6, that specifically binds to native PORCN. The binding of clone VS0724W6 to PORCN does not interfere with PORCN activity. The immunogen was purified recombinant human PORCN reconstituted with amphiphilic polymers.
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Custom Production
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Specifications
- Immunogen
- Recombinant human PORCN reconstituted with amphiphilic polymers.
- Host Species
- Mouse
- Derivation
- Hybridoma
- Type
- Mouse IgG
- Specificity
- Human PORCN
- Species Reactivity
- Human
- Clone
- VS0724W6
- Applications
- ELISA, Western Blot, Immunoprecipitation
- Related Disease
- Focal Dermal Hypoplasia and Macs Syndrome
Product Property
- Clonality
- Monoclonal Antibody
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Protein-serine O-palmitoleoyltransferase porcupine; PORCN
- Gene ID
- 64840
- UniProt ID
- Q9H237
- Long Name
- Protein-serine O-palmitoleoyltransferase porcupine
- Sequence Similarities
- Belongs to the membrane-bound acyltransferase family.
- Cellular Localization
- Endoplasmic reticulum membrane
- Post Translation Modifications
- Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- XP_047298313.1; XP_047298314.1; XP_047298315.1; XP_047298316.1; XP_047298317.1
- Function
- Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins.
Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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For Research Use Only. Not For Clinical Use.
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