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    Rabbit Anti-PPP3CA Recombinant Antibody (clone R09-6K9) (CAT#: VS3-XY3475)

    This product is a recombinant rabbit antibody binding to PPP3CA (Protein phosphatase 3 catalytic subunit alpha), which positively regulates osteoclast differentiation, potentially via NFATC1 signaling. PPP3CA may play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling. This antibody specifically reacts with human, mouse and rat PPP3CA. It has been detected by Western Blot, Flow cytometry, Immunocytochemistry or Immunofluorescence.

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    • Purity:

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    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line A-431
    Figure 1 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/18581/if_selected.jpg
    Normal Tissue
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Glial cells
    Staining: Low
    Intensity: Moderate
    Quantity: <25%
    Location: Cytoplasmic/membranous
    Neuronal cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous nuclear
    Neuropil
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/12778/42715_B_7_5.jpg
    Figure 3 Testis
    Figure 3 Testis
    (Leydig cells
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/12778/42715_A_6_6.jpg
    Figure 4 Prostate
    Figure 4 Prostate
    (Glandular cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/12778/42715_A_3_5.jpg
    Figure 5 Lymph node
    Figure 5 Lymph node
    (Non-germinal center cells
    Staining: Low
    Intensity: Weak
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/12778/42715_A_7_8.jpg
    RNA Expression
    Figure 6 RNA cell line category: Low cell line specificity
    Figure 6 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138814-PPP3CA/subcellular

    Specifications

    • Host Species
    • Rabbit
    • Type
    • Rabbit IgG
    • Specificity
    • Human, Mouse and Rat PPP3CA
    • Species Reactivity
    • Human, Mouse, Rat
    • Clone
    • R09-6K9
    • Applications
    • WB, ICC, IF, FC
    • Related Disease
    • Arthrogryposis, Cleft Palate, Craniosynostosis, And Impaired Intellectual Development

    Product Property

    • Clonality
    • Monoclonal
    • Aggregation
    • < 5%
    • Format
    • Liquid
    • Buffer
    • PBS (pH 7.4), 150 mM NaCl and 50% glycerol
    • Preservative
    • 0.02% sodium azide
    • Storage
    • Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • WB: 1/500-1/1000
      IF: 1/50-1/200
      FC: 1/50-1/100

    Target

    • Alternative Names
    • CALN; CCN1; CNA1; CALNA; DEE91; IECEE; PPP2B; ACCIID; CALNA1; IECEE1
    • Long Name
    • Protein phosphatase 3 catalytic subunit alpha
    • Cellular Localization
    • Cytoplasm, Cell membrane
    • Post Translation Modifications
    • Ubiquitination at Lys32 and Lys142 (NX_Q08209 [NX_Q08209-1])
      Modification sites at PhosphoSitePlus (Q08209)
      Glycosylation from GlyGen (Q08209) 1 site, 1 O-linked glycan (1 site)
    • Function
    • In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020).
      In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687).
      Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity).
      Dephosphorylates heat shock protein HSPB1 (By similarity).
      Dephosphorylates and activates transcription factor NFATC1.

    Recommended Products

    Isotype Control

    Recommended Dilution Buffer

    Secondary Antibody

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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    Rabbit Monoclonal Antibody Products IgG Antibody Products IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
    CAT Product Name Application Type
    MOR-2830 Hi-Affi™ Recombinant Rabbit Anti-PPP3CA Monoclonal Antibody (DS2830AB) WB, ICC, FC IgG

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