Rabbit Anti-PRKCQ Recombinant Antibody (VS13-YC941) (CAT#: VS13-YC941)

• Immunogen
• Recombinant human PRKCQ.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human PRKCQ

• Species Reactivity
• Human

• Applications
• IHC-P

• Conjugate
• NONE

• Related Disease
• Inflammatory Bowel Disease and Gastrointestinal Stromal Tumor

• Clonality
• Monoclonal

• Purification
• Affinity Chromatography purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS (pH 7.2) containing 50% Glycerol and 0.5% BSA.

• Preservative
• 0.02% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Immunohistochemistry (IHC): 1/100-1/200

• Alternative Names
• PRKCT; nPKC-theta

• Gene ID
• 5588

• UniProt ID
• Q04759

• Long Name
• protein kinase C theta

• Sequence Similarities
• Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

• Cellular Localization
• Cell membrane; Cytoplasm; Membrane

• Protein Refseq
• XP_005252553.1; XP_005252554.1; XP_054222269.1; XP_054222270.1; NP_001229342.1

• Function
• Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1, 4, 5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response.

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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