Anti-PRSS2 (clone W24V239) Recombinant Antibody Coupled Liposome (VS-1024-FY236)
CAT#: VS-1024-FY236
Anti-PRSS2 antibody conjugated liposomes present a promising approach for targeted therapy in pancreatic cancer by selectively delivering therapeutic agents to PRSS2-expressing tumor cells. This targeted delivery system can enhance the effectiveness of chemotherapy or immunotherapy while reducing off-target effects, improving patient outcomes. Additionally, the liposome's biodegradable nature and ability to encapsulate both small molecules and larger biologics make it a versatile platform for combination therapies. Ultimately, this innovative strategy could pave the way for more personalized treatment options in pancreatic cancer, a disease notoriously resistant to conventional therapies.
More Infomation
Specifications
- Potential Clinical Applications
- Pancreatic cancer
Product Composition
- Clone
- W24V239
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that was created to bind specifically to PRSS2. By focusing on this serine protease, the antibody aids researchers in exploring its implications in pancreatic disorders and digestion processes. The specificity of this monoclonal antibody allows for detailed studies that can lead to better understanding and treatment of related diseases.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- PRSS2
- Introduction
- This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.
- Alternative Names
- TRY2; TRY8; TRYP2
- Full Name
- Putative trypsinogen
- Gene ID
- 5645
- UniProt ID
- P07478
- Sequence Similarities
- Belongs to the peptidase S1 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Sulfated on tyrosine.
Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.
- Protein Refseq
- NP_002761.1
- Function
- In the ileum, may be involved in defensin processing, including DEFA5.
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See other products for "PRSS2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3061z | Mouse Anti-PRSS2 Recombinant Antibody (clone 36H4) | WB, IP | Mouse IgG1 |
| VS4-CJ94 | Recombinant Rabbit Anti-PRSS2 Antibody (clone 12H7) | ELISA, IF | Rabbit IgG |
| VS13-YC947 | Rabbit Anti-PRSS2 Recombinant Antibody (VS13-YC947) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2878 | Hi-Affi™ Recombinant Rabbit Anti-PRSS2 Monoclonal Antibody (DS2878AB) | WB, ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5754 | Anti-PRSS2 Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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