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PRSS2

Anti-PRSS2 Products
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IF
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP
- Anti-PRSS2 Immunohistochemistry Kit (VS-0525-XY5754)
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- Species Reactivity: Human
- Target: PRSS2
- Application: IHC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, ELISA
- Rabbit Anti-PRSS2 Recombinant Antibody (VS13-YC947) (VS13-YC947)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
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- Antibody Host: Mouse
- Antibody Reactivity: Human
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For Research Use Only. Not For Clinical Use.
Background
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix.
Protein class
Enzymes, Human disease related genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enriched (Exocrine glandular cells)
Immune cell specificity
Group enriched (basophil, T-reg)
Cell line specificity
Cell line enhanced (OE19, RPMI-8226, U-2 OS)
Molecular function
Hydrolase, Protease, Serine protease
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