Rabbit Anti-PVR Recombinant Antibody (clone R01-8A1) (CAT#: VS3-FY2066)
The anti-Poliovirus receptor antibody detected positive in western blot analysis of poliovirus receptor/PVR in Hela, A549, U2OS lysates. The recombinant monoclonal antibody exhibits selective binding to human PVR.
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WB
Figure 1 Anti-PVR Antibody (VS3-FY2066) in WB.
The Poliovirus Receptor/PVR expression in Hela, A549, U2OS lysates were detected using the anti-Poliovirus Receptor by western blot assay.
Specifications
- Immunogen
- Recombinant human poliovirus receptor/PVR protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human PVR
- Species Reactivity
- Human
- Clone
- R01-8A1
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 45 kDa, while the observed molecular weight stands at 60-80 kDa.
- Related Disease
- Poliomyelitis and Paralytic Poliomyelitis
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- PVR; PVS; Poliovirus receptor; Nectin-like protein 5; NECL-5; CD155
- Gene ID
- 5817
- UniProt ID
- P15151
- Sequence Similarities
- Belongs to the nectin family.
- Cellular Localization
- Cell membrane, Membrane, Secreted
- Post Translation Modifications
- N-glycosylated.
N-glycan at Asn-120: Hex5HexNAc4.
(P15151-PVR_HUMAN)
Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation.
Interaction with TIGIT is required for Phosphorylation.
(P15151-PVR_HUMAN)
Glycosylation at Asn105, Asn120, Asn188, Asn218, Asn237, Asn278, Asn307, and Asn313 (NX_P15151 [NX_P15151-1])
Modification sites at PhosphoSitePlus (P15151)
Glycosylation from GlyConnect PVR_HUMAN (782)
Glycosylation from GlyGen (P15151) 13 sites, 2 N-linked glycans (1 site), 2 O-linked glycans (3 sites)
- Protein Refseq
- NP_001129240.1; NP_001129241.1; NP_001129242.2; NP_006496.4
- Function
- Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3400z | Mouse Anti-PVR Recombinant Antibody (clone 35G12) | WB, FC, ICC, IF | Mouse IgG1 |
| MOB-0791MZ | Recombinant Mouse Anti-Human PVR Antibody (clone E282) | FC, ICC/IF | Mouse antibody |
| FN-074CQ | Recombinant Mouse Anti-PVR Antibody (4.24) | FC, FuncS | Mouse IgG2a |
| VS3-FY1229 | Recombinant Rabbit Anti-PVR Antibody (clone R04-2C7) | WB, IHC-P | Rabbit IgG |
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