Recombinant Anti-PVRIG Vesicular Antibody, EV Displayed (VS-0425-YC456)
CAT#: VS-0425-YC456
The Recombinant Anti-PVRIG Vesicular Antibody, EV Displayed (VS-0425-YC456) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PVRIG-expressed cells or tissues. The PVRIG is a receptor involved in immune regulation, particularly in T cell signaling pathways.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoli & endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/1365_E3_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human pancreas
Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glial cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_A_7_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_A_9_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_A_4_6.jpg
Normal Tissue
Figure 8 Lymph node
Non-germinal center cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Group enriched (Daudi, JURKAT, MOLT-4, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000213413-PVRIG/subcellular
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Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PVRIG
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Cynomolgus
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- PVR related immunoglobulin domain containing
- Introduction
- Enables phosphatase binding activity and signaling receptor activity. Involved in negative regulation of T cell receptor signaling pathway. Located in plasma membrane.
- Alternative Names
- C7orf15, CD112R, MGC2463
- Gene ID
- 79037
- UniProt ID
- Q6DKI7
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Downloadable Resources
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Datasheet
MSDS
COA
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See other products for "PVRIG"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0774LY-S(P) | Human Anti-PVRIG Recombinant Antibody; scFv Fragment (HPAB-0774LY-S(P)) | ELISA, FC, WB, Block | Human scfv |
| HPAB-0775LY-S(P) | Human Anti-PVRIG Recombinant Antibody; scFv Fragment (HPAB-0775LY-S(P)) | ELISA, FC, WB, Block | Human scfv |
| HPAB-0776LY-S(P) | Human Anti-PVRIG Recombinant Antibody; scFv Fragment (HPAB-0776LY-S(P)) | ELISA, FC, WB, Block | Human scfv |
| HPAB-0777LY-S(P) | Human Anti-PVRIG Recombinant Antibody; scFv Fragment (HPAB-0777LY-S(P)) | ELISA, FC, WB, Block | Human scfv |
| HPAB-0778LY-S(P) | Human Anti-PVRIG Recombinant Antibody; scFv Fragment (HPAB-0778LY-S(P)) | ELISA, FC, WB, Block | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0774LY | Human Anti-PVRIG Recombinant Antibody (HPAB-0774LY) | ELISA, FC, WB, Block | Human IgG |
| HPAB-0775LY | Human Anti-PVRIG Recombinant Antibody (HPAB-0775LY) | ELISA, FC, WB, Block | Human IgG |
| HPAB-0776LY | Human Anti-PVRIG Recombinant Antibody (HPAB-0776LY) | ELISA, FC, WB, Block | Human IgG |
| HPAB-0777LY | Human Anti-PVRIG Recombinant Antibody (HPAB-0777LY) | ELISA, FC, WB, Block | Human IgG |
| HPAB-0778LY | Human Anti-PVRIG Recombinant Antibody (HPAB-0778LY) | ELISA, FC, WB, Block | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0774LY-F(E) | Human Anti-PVRIG Recombinant Antibody; Fab Fragment (HPAB-0774LY-F(E)) | ELISA, FC, WB, Block | Human Fab |
| HPAB-0775LY-F(E) | Human Anti-PVRIG Recombinant Antibody; Fab Fragment (HPAB-0775LY-F(E)) | ELISA, FC, WB, Block | Human Fab |
| HPAB-0776LY-F(E) | Human Anti-PVRIG Recombinant Antibody; Fab Fragment (HPAB-0776LY-F(E)) | ELISA, FC, WB, Block | Human Fab |
| HPAB-0777LY-F(E) | Human Anti-PVRIG Recombinant Antibody; Fab Fragment (HPAB-0777LY-F(E)) | ELISA, FC, WB, Block | Human Fab |
| HPAB-0778LY-F(E) | Human Anti-PVRIG Recombinant Antibody; Fab Fragment (HPAB-0778LY-F(E)) | ELISA, FC, WB, Block | Human Fab |
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