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    Recombinant Anti-PVRIG Vesicular Antibody, EV Displayed (VS-0425-YC456) (CAT#: VS-0425-YC456)

    The Recombinant Anti-PVRIG Vesicular Antibody, EV Displayed (VS-0425-YC456) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PVRIG-expressed cells or tissues. The PVRIG is a receptor involved in immune regulation, particularly in T cell signaling pathways.

    Specific Inquiry
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line A-431
    Figure 1 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoli & endoplasmic reticulum.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/1365_E3_2_selected.jpg
    Figure 2 IHC staining of human pancreas
    Figure 2 IHC staining of human pancreas
    (Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/ihc_selected.jpg
    Normal Tissue
    Figure 3 Cerebral cortex
    Figure 3 Cerebral cortex
    (Endothelial cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Glial cells
    Staining: Not detected
    Intensity: Weak
    Quantity: <25%
    Location: Cytoplasmic/membranous
    Neuronal cells
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Neuropil
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_B_9_5.jpg
    Figure 4 Colon
    Figure 4 Colon
    (Endothelial cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Glandular cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Peripheral nerve/ganglion
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_A_7_3.jpg
    Figure 5 Liver
    Figure 5 Liver
    (Hepatocytes
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_A_7_4.jpg
    Figure 6 Kidney
    Figure 6 Kidney
    (Cells in tubules
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_A_9_5.jpg
    Figure 7 Testis
    Figure 7 Testis
    (Cells in seminiferous ducts
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Leydig cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_A_4_6.jpg
    Figure 8 Lymph node
    Figure 8 Lymph node
    (Non-germinal center cells
    Staining: Low
    Intensity: Moderate
    Quantity: <25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_A_9_8.jpg
    RNA Expression
    Figure 9 RNA cell line category: Group enriched (Daudi, JURKAT, MOLT-4, U-698)
    Figure 9 RNA cell line category: Group enriched (Daudi, JURKAT, MOLT-4, U-698)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000213413-PVRIG/subcellular

    Recombinant Antibody

    • Application
    • Block, ELISA, FC, Cell-uptake
    • Product Type
    • Ab-Fc-EVs
    • Antibody Quantification (Ab/EV)
    • ~100 Ab/EV
    • Target
    • PVRIG
    • Host Animal
    • Human
    • Antibody Isotype
    • IgG
    • Species Reactivity
    • Human, Cynomolgus
    • Expression Cell
    • Mammalian cell

    Engineered EVs

    • EV-sorting domain
    • CD63
    • Fc-binding domain
    • z domain
    • EV Size
    • 30~150 nm
    • Producing Cell
    • HEK293F
    • Isolation Method
    • Gradient centrifugation
    • Purification
    • qEV size exclusion chromatography
    • Binding Affinity
    • Kd = 0.85 µg/mL
    • Concentration
    • 1 x 10¹⁰
    • Size
    • 1 mL
    • Buffer
    • PBS
    • Storage
    • Store at -80°C for 12 months

    Target

    • Full Name
    • PVR related immunoglobulin domain containing
    • Introduction
    • Enables phosphatase binding activity and signaling receptor activity. Involved in negative regulation of T cell receptor signaling pathway. Located in plasma membrane.
    • Alternative Names
    • C7orf15, CD112R, MGC2463

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "PVRIG"

    Select a product category from the dropdown menu below to view related products.
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    ScFv Antibody Products IgG Antibody Products Fab Antibody Products
    CAT Product Name Application Type
    HPAB-0774LY-S(P) Human Anti-PVRIG Recombinant Antibody; scFv Fragment (HPAB-0774LY-S(P)) ELISA, FC, WB, Block Human scfv
    HPAB-0775LY-S(P) Human Anti-PVRIG Recombinant Antibody; scFv Fragment (HPAB-0775LY-S(P)) ELISA, FC, WB, Block Human scfv
    HPAB-0776LY-S(P) Human Anti-PVRIG Recombinant Antibody; scFv Fragment (HPAB-0776LY-S(P)) ELISA, FC, WB, Block Human scfv
    HPAB-0777LY-S(P) Human Anti-PVRIG Recombinant Antibody; scFv Fragment (HPAB-0777LY-S(P)) ELISA, FC, WB, Block Human scfv
    HPAB-0778LY-S(P) Human Anti-PVRIG Recombinant Antibody; scFv Fragment (HPAB-0778LY-S(P)) ELISA, FC, WB, Block Human scfv

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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