Rabbit Anti-RAB11A Recombinant Antibody (clone R06-7F2)
CAT#: VS3-XY3484
It is a recombinant rabbit antibody targeting the RAB11A (RAB11A, member RAS oncogene family), which acts as a major regulator of membrane delivery during cytokinesis. RAB11A may also play a role in melanosome transport and release from melanocytes. The antibody specifically reacts with human, mouse and rat RAB11A. It has been determined using Western Blot and Immunoprecipitation. The recommended dilutions of Western Blot and Immunoprecipitation is 1/500-1/1000 and 1/20, respectively.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to centriolar satellites & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/51697/769_D6_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human stomach
Immunohistochemical staining of human stomach shows strong cytoplasmic and membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/60686/ihc_selected.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/60686/143716_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/60686/143716_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/60686/143716_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/60686/143716_A_5_6.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000103769-RAB11A
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat RAB11A
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R06-7F2
- Applications
- WB, IP
- Related Disease
- Autosomal Dominant Non-Syndromic Intellectual Disability; Primary Microcephaly
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IP: 1/20
Target
- Alternative Names
- YL8
- Gene ID
- 8766
- UniProt ID
- P62491
- Long Name
- RAB11A, member RAS oncogene family
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- (Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3. (P62491-RB11A_HUMAN)
Ubiquitination at Lys179 and Lys207 (NX_P62491 [NX_P62491-1])
Modification sites at PhosphoSitePlus (P62491)
Glycosylation from GlyGen (P62491) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_004654.1
- Function
- The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.
Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.
The small Rab GTPase RAB11A regulates endocytic recycling.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "RAB11A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2954 | Hi-Affi™ Recombinant Rabbit Anti-RAB11A Monoclonal Antibody (DS2954AB) | WB, IP | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-CJ1089 | Mouse Anti-RAB11A Recombinant Antibody (VS3-CJ1089) | WB, IHC-P | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5911 | Anti-RAB11A Immunohistochemistry Kit | IHC |
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