Mouse Anti-RAB11A Recombinant Antibody (VS3-CJ1089) (CAT#: VS3-CJ1089)

• Immunogen
• Purified recombinant protein of human RAB11A

• Host Species
• Mouse

• Type
• Mouse IgG1, κ

• Specificity
• Human, Mouse, Rat RAB11A

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB, IHC-P

• Conjugate
• Unconjugated

• Purification
• Protein A/G affinity purified

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Buffer
• PBS, pH 7.3.

• Preservative
• 0.09% Sodium Azide

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• This antibody has been tested for use in Western Blot (1:4000), Immunohistochemistry-Parraffin (1:25).

• Alternative Names
• YL8

• Gene ID
• 8766

• UniProt ID
• P62491

• Sequence Similarities
• Belongs to the small GTPase superfamily. Rab family.

• Cellular Localization
• Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

• Post Translation Modifications
• (Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3.

• Protein Refseq
• NP_001193765.1; NP_004654.1

• Function
• The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.

Secondary Antibody

• 2RD-A1460-YJ
• Goat Anti-Mouse IgG1 Secondary antibody

• 2RD-A1562-YJ
• Rabbit Anti-Mouse IgG1 Secondary antibody (Clone RM106)

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

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