Mouse Anti-Rab3a Recombinant Antibody (clone 6D1A12)
CAT#: VS7-0425-WR741
This product is a mouse IgG1 antibody that binds to human Rab3a. The antibody 6D1A12 recognizes specific amino acid domain of human Rab3a (AA: 1-220). It can be used for FC assay.
Specifications
- Immunogen
- Recombinant human Rab3a (AA: 1-220) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human Rab3a
- Species Reactivity
- Human
- Clone
- 6D1A12
- Molecule Class
- Small GTPases
- Applications
- FC
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Flow Cytometry: 1:200 - 1:400
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- RAB3A, member RAS oncogene family
- Gene ID
- 5864
- UniProt ID
- P20336
- Long Name
- RAB3A, member RAS oncogene family
- Cellular Localization
- Cell membrane; Cell projection; Cytoplasm; Cytoplasmic vesicle; Lysosome; Membrane; Synapse
- Post Translation Modifications
- Lipoprotein; Methylation; Phosphoprotein; Prenylation
- Protein Refseq
- NP_002857.1
- Function
- Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity).; Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity).; Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity).; Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity).; Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (PubMed:27325790).; Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (PubMed:22248876, PubMed:30599141).; Also plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity).; Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
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Secondary Antibody
- CAT
- Product Name
Reconstitution Buffer
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
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See other products for "RAB3A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX946 | Mouse Anti-RAB3A Recombinant Antibody (clone D1-12) | WB, FC | Mouse IgG1 |
| VS3-CJ768 | Mouse Anti-RAB3A Recombinant Antibody (VS3-CJ768) | WB, ICC, FC | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1853 | Anti-RAB3A Immunohistochemistry Kit | IHC | |
| VS-0525-XY5924 | Anti-Mouse RAB3A Immunohistochemistry Kit | IHC | |
| VS-0525-XY5923 | Anti-Human RAB3A Immunohistochemistry Kit | IHC |
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