Mouse Anti-RAB3A Recombinant Antibody (VS3-CJ768)
CAT#: VS3-CJ768
This product is a mouse antibody that recognizes human, mouse, and rat RAB3A.
Specifications
- Immunogen
- Recombinant protein
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human, Mouse, Rat RAB3A
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ICC, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS
- Preservative
- 0.09% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:2000), Immunocytochemistry (1:25), Flow Cytometry (1:25).
Target
- Alternative Names
- RAB3A, member RAS oncogene family
- Gene ID
- 5864
- UniProt ID
- P20336
- Sequence Similarities
- Belongs to the small GTPase superfamily. Rab family.
- Cellular Localization
- Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Lysosome, Membrane, Synapse
- Post Translation Modifications
- Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
- Protein Refseq
- NP_002857.1
- Function
- Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity).
Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity).
Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity).
Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity).
Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (PubMed:27325790).
Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (PubMed:22248876, PubMed:30599141).
Also plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity).
Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "RAB3A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX946 | Mouse Anti-RAB3A Recombinant Antibody (clone D1-12) | WB, FC | Mouse IgG1 |
| VS7-0425-WR741 | Mouse Anti-Rab3a Recombinant Antibody (clone 6D1A12) | FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1853 | Anti-RAB3A Immunohistochemistry Kit | IHC | |
| VS-0525-XY5924 | Anti-Mouse RAB3A Immunohistochemistry Kit | IHC | |
| VS-0525-XY5923 | Anti-Human RAB3A Immunohistochemistry Kit | IHC |
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