Rabbit Anti-RBX1 Recombinant Antibody (VS13-YC994)
CAT#: VS13-YC994
The Rabbit Anti-RBX1 Recombinant Antibody is specific for human RBX1. RBX1 encodes a RING finger-like protein interacting with cullin proteins, contributing to ubiquitination processes essential for cell cycle progression, with related pseudogenes on chromosomes 2 and 5. The anti-RBX1 antibody can be used for Immunohistochemistry (1/100-1/200).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3038/1042_A5_1_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000100387-RBX1
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Specifications
- Immunogen
- Recombinant human ROC1.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human RBX1
- Species Reactivity
- Human
- Applications
- IHC-P
- Conjugate
- NONE
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.2) containing 50% Glycerol and 0.5% BSA.
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Immunohistochemistry (IHC): 1/100-1/200
Target
- Alternative Names
- Ring-Box 1; Regulator Of Cullins 1; RING Finger Protein 75; RING-Box Protein 1; RNF75; ROC1; Ring-Box 1, E3 Ubiquitin Protein Ligase;
- Gene ID
- 9978
- UniProt ID
- P62877
- Long Name
- Ring-Box 1
- Sequence Similarities
- Belongs to the RING-box family.
- Cellular Localization
- Cytoplasm; Nucleus
- Protein Refseq
- NP_055063.1
- Function
- E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.
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Related Signaling Pathways
TGF-β Signaling Pathway
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "RBX1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3032 | Hi-Affi™ Recombinant Rabbit Anti-RBX1 Monoclonal Antibody (DS3032AB) | WB, IHC, ICC, IP, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2155-CN | Rabbit Anti-RBX1 Polyclonal Antibody (MRO-2155-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-CJ1099 | Mouse Anti-RBX1 Recombinant Antibody (VS3-CJ1099) | WB | Mouse IgG1, κ |
| VS3-XY1366 | Mouse Anti-RBX1 Recombinant Antibody (clone 3G7) | WB, IP, IF | Mouse IgG1 |
| VS3-FY1261 | Recombinant Rabbit Anti-RBX1 Antibody (clone R07-3F6) | WB, IHC-Fr, IHC-P, ICC, IF, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1897 | Anti-RBX1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6052 | Anti-Human RBX1 Immunohistochemistry Kit | IHC |
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