Mouse Anti-RTN3 Monoclonal Antibody (VS7-0425-WR800)
CAT#: VS7-0425-WR800
This product is a mouse IgG antibody that binds to human RTN3. The antibody can be used for IHC-P, IF, and ELISA assays.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15650/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15650/35807_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15650/35807_A_7_3.jpg
RNA Expression
Figure 4 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000133318-RTN3
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Specifications
- Immunogen
- Recombinant human RTN3 fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human RTN3
- Species Reactivity
- Human
- Molecule Class
- Reticulon Family
- Applications
- IHC-P, IF, ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis, Ascitic fluid
- Format
- Liquid
- Concentration
- 1 mg/ml
- Preservative
- 0.03% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Aliquot and store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Immunohistochemistry: 1:200 - 1:1000
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- Reticulon 3; Neuroendocrine-Specific Protein-Like 2; Homolog Of ASY Protein; NSP-Like Protein II; Neuroendocrine-Specific Protein-Like II; ASY Interacting Protein; NSP-Like Protein 2; NSPLII
- Gene ID
- 10313
- UniProt ID
- O95197
- Long Name
- Reticulon 3
- Cellular Localization
- Endoplasmic reticulum; Golgi apparatus; Membrane
- Post Translation Modifications
- Acetylation; Phosphoprotein
- Protein Refseq
- NP_001252518.1
- Function
- May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671).; Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "RTN3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1055CT | Recombinant Mouse anti-Human RTN3 Monoclonal antibody (20B9) | ELISA, IHC-P | |
| ZG-075R | Mouse Anti-RTN3 Recombinant Antibody (ZG-075R) | IF, ELISA | Mouse IgG |
| ZG-076R | Mouse Anti-RTN3 Recombinant Antibody (ZG-076R) | ELISA, IHC | Mouse IgG |
| VS3-QX989 | Mouse Anti-RTN3 Recombinant Antibody (clone 10A8) | WB, IHC, ICC, FC, ELISA | Mouse IgG2a |
| VS7-0425-WR801 | Mouse Anti-RTN3 Monoclonal Antibody (VS7-0425-WR801) | IF, ICC, ELISA | Mouse IgG |
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