Mouse Anti-S100A1 Monoclonal Antibody (clone 2C8B8) (CAT#: VS7-0425-WR809)
This product is a mouse IgG1 antibody that binds to human S100A1. The antibody 2C8B8 can be used for IHC assay.
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm, cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6462/1662_G4_2_selected.jpg
(Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm, cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6462/1662_G4_2_selected.jpg
Figure 2 Heart muscle
(Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6462/20242_B_4_6.jpg
(Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6462/20242_B_4_6.jpg
Figure 3 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6462/20242_B_9_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6462/20242_B_9_5.jpg
Figure 4 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6462/20242_A_9_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6462/20242_A_9_5.jpg
Figure 5 RNA cell line category: Group enriched (Hep G2, SK-MEL-30)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160678-S100A1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160678-S100A1
Specifications
- Immunogen
- Recombinant human S100A1 fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human S100A1
- Species Reactivity
- Human
- Clone
- 2C8B8
- Molecule Class
- EF-Hand Calcium-Binding Protein Family
- Applications
- IHC
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis, Ascitic fluid
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Preservative
- 0.03% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Immunohistochemistry-Paraffin: 1:200 - 1:1000
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- S100A1; S100 Alpha; Protein S100-A1; S-100 Protein Subunit Alpha; S100 Calcium-Binding Protein A1; S100 Protein, Alpha Polypeptide; S100; S100 Calcium Binding Protein A1; S-100 Protein Alpha Chain; S100-Alpha
- Gene ID
- 6271
- UniProt ID
- P23297
- Long Name
- S100 Calcium Binding Protein A1
- Cellular Localization
- Cytoplasm; Mitochondrion; Sarcoplasmic reticulum
- Post Translation Modifications
- Glutathionylation; S-nitrosylation
- Protein Refseq
- NP_006262.1
- Function
- Small calcium binding protein that plays important roles in several biological processes such as Ca2+ homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600).; In response to an increase in intracellular Ca2+ levels, binds calcium which triggers conformational changes (PubMed:23351007).; These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290).; Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca2+ cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca2+-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600).; Facilitates diastolic Ca2+ dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3941z | Mouse Anti-S100A1 Recombinant Antibody (clone 9H7) | WB, ELISA, IHC | Mouse IgG1 |
| MRO-1354-CN | Recombinant Rabbit Anti-S100A1 Monoclonal Antibody (JM51-31) | WB, IP, IHC, FC | Rabbit IgG |
| ZG-0390U | Rabbit Anti-S100A1 Recombinant Antibody (clone Q17-N) | ICC | Rabbit IgG |
| VS3-WK209 | Mouse Anti-S100A1 Recombinant Antibody (clone VS3-WK209) | ELISA, CLIA, RIA, IHC, WB | Mouse IgG |
| VS3-WK591 | Rabbit Anti-S100A1 Recombinant Antibody (clone JM51-31) | WB, IP, IHC, FC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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