AibGenesis™ Rabbit Anti-S100A1 Recombinant Antibody (AibG-Rb-S1726)
CAT#: VS-0426-FY726
Engineered via an AI-powered antibody discovery platform, this S100A1 antibody aids heart failure research, ensuring specific detection in human and rat tissue.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm, cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6462/1662_G4_2_selected.jpg
Normal Tissue
Figure 2 Heart muscle
Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6462/20242_B_4_6.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6462/20242_B_9_5.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6462/20242_A_9_5.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (Hep G2, SK-MEL-30)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160678-S100A1
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Specifications
- Immunogen
- Human
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human S100A1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- AibG-Rb-S1726
- Applications
- Western Blot, Immunohistochemistry, Immunofluorescence-Paraffin
- Conjugate
- Unconjugated, Biotin and FITC are available.
- Related Disease
- Heart Failure
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- PBS, pH 7.4, 150 mM NaCl, 50% Glycerol
- Preservative
- 0.02% New type preservative N
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (1:500-1:2000), Immunohistochemistry (1:100-1:200), Immunofluorescence-Paraffin (1:100-1:200)
Target
- Alternative Names
- Bpb; NEF; Protein S100-A1; S100 beta; S100 calcium binding protein A1; S100A; S100B; 100beta
- Gene ID
- 6271
- UniProt ID
- P23297
- Long Name
- S100 Calcium Binding Protein A1
- Sequence Similarities
- Belongs to the S-100 family.
- Cellular Localization
- Cytoplasm, Mitochondrion, Sarcoplasmic reticulum
- Post Translation Modifications
- Glutathionylated; glutathionylation increases affinity to calcium about 10-fold.
- Protein Refseq
- NP_006262.1
- Function
- Small calcium binding protein that plays important roles in several biological processes such as Ca²⁺ homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600).
In response to an increase in intracellular Ca²⁺ levels, binds calcium which triggers conformational changes (PubMed:23351007).
These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290).
Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca²⁺ cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca²⁺-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600).
Facilitates diastolic Ca²⁺ dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "S100A1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3941z | Mouse Anti-S100A1 Recombinant Antibody (clone 9H7) | WB, ELISA, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1444MZ | Recombinant Mouse Anti-Human S100A1 Antibody (clone 9C20) | ELISA, ICC, IF, WB, sELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1354-CN | Recombinant Rabbit Anti-S100A1 Monoclonal Antibody (JM51-31) | WB, IP, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1251CQ | Mouse Anti-S100A1 Recombinant Antibody (clone S1-61) | WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0356U | Rabbit Anti-S100A1 Recombinant Antibody (clone D28-E) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1986 | Anti-S100A1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6293 | Anti-Human S100A1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6294 | Anti-Mouse S100A1 Immunohistochemistry Kit | IHC |
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