Human Anti-SARS-CoV-2 S Recombinant Antibody (clone 4A8)
CAT#: VS-0126-FY175
The SARS-CoV-2 S antibody (VS-0126-FY175) is a high-affinity Human monoclonal antibody developed for specific SARS-CoV-2 spike protein detection. Generated using purified antigen, this reagent ensures exceptional precision. It is validated for neutralization and flow cytometry, recognizing loops N3 and N5 of the N-terminal domain (NTD). With demonstrated reactivity across SARS-CoV-2, this antibody serves as a reliable tool for advanced research into NTD-directed neutralization and the functional role of non-RBD spike domains in infection.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Antibody Isotype
- IgG
- Specificity
- Specific to SARS-CoV-2. (Sequence alignment suggests variations in the NTD surface compared to SARS-CoV and MERS-CoV, implying specificity).
- Species Reactivity
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
- Clone
- 4A8
- Applications
- Neutralization, Flow Cytometry
- Related Disease
- Severe Acute Respiratory Syndrome Coronavirus 2
Product Property
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Neutralized HIV-vectored pseudotyped SARS-CoV-2 in ACE2-293T cells (EC₅₀= 49 µg/mL).
Target
- Alternative Names
- Spike Protein, S Glycoprotein, Peplomer protein
- Long Name
- SARS-CoV-2 Spike Protein
- Function
- The Spike protein mediates viral entry into host cells by binding to the ACE2 receptor and facilitating membrane fusion. It is the primary target for neutralizing antibodies and vaccine development.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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| VS3-WK1511 | Human Anti-SARS-CoV-2 S Recombinant Antibody (VS3-WK1511) | WB, ELISA | Human IgG |
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| VS3-WK1512 | Human Anti-SARS-CoV-2 S Recombinant Antibody (VS3-WK1512) | WB, ELISA | Human IgM |
| CAT | Product Name | Application | Type |
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| VS3-WK1530 | Human Anti-SARS-CoV-2 S Recombinant Antibody (clone S1) | WB, ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
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| VS3-WK1531 | Human Anti-SARS-CoV-2 S Recombinant Antibody (clone S1a) | ELISA | Humanized IgG1 |
| CAT | Product Name | Application | Type |
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| VS3-WK1532 | Human Anti-SARS-CoV-2 S Recombinant Antibody (clone BS01) | WB, ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
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| VS3-WK1533 | Human Anti-SARS-CoV-2 S Recombinant Antibody (clone BS02) | WB, ELISA | Humanized IgG |
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| VS3-WK1534 | Human Anti-SARS-CoV-2 S Recombinant Antibody (clone BS03) | WB, ELISA | Humanized IgG |
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| VS3-WK1539 | Human Anti-SARS-CoV-2 S Recombinant Antibody (clone BSM01) | WB, ELISA | Human IgM |
| CAT | Product Name | Application | Type |
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| VS3-WK1542 | Human Anti-SARS-CoV-2 S Recombinant Antibody (clone SG01) | WB, ELISA | Human IgG |
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