Rabbit Anti-SBDS Recombinant Antibody (clone R02-2G2) (CAT#: VS3-FY2084)
The anti-SBDS antibody detected positive in western blot analysis of SBDS in A549, HL-60, U2OS, U87-MG lysates. The recombinant monoclonal antibody is meticulously crafted to specifically target human SBDS. It is suitable for use in a variety of assays, including WB, ICC/IF, IP.
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WB
Figure 1 Anti-SBDS Antibody (VS3-FY2084) in WB.
The SBDS expression in A549, HL-60, U2OS, U87-MG lysates were detected using the anti-SBDS by western blot assay.
ICC
Figure 2 Anti-SBDS Antibody (VS3-FY2084) in ICC.
Immunocytochemistry staining of SBDS (green) in Hela using the anti-SBDS antibody. Nuclear DNA was labeled with DAPI (shown in blue).
Specifications
- Immunogen
- Synthetic peptide of human SBDS
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human SBDS
- Species Reactivity
- Human
- Clone
- R02-2G2
- Applications
- Western Blot, Immunofluorescence, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 29 kDa, while the observed molecular weight stands at 29 kDa.
- Related Disease
- Shwachman-Diamond Syndrome 1 and Aplastic Anemia
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunofluorescence: 1/50-1/200
Immunoprecipitation: 1/20
Target
- Alternative Names
- SBDS, Ribosome Maturation Factor; SBDS, Ribosome Assembly Guanine Nucleotide Exchange Factor; Shwachman-Bodian-Diamond Syndrome Protein; Shwachman-Bodian-Diamond Syndrome; Ribosome Maturation Protein SBDS; CGI-97; SWDS; SDS
- Gene ID
- 51119
- UniProt ID
- Q9Y3A5
- Sequence Similarities
- Belongs to the SDO1/SBDS family.
- Cellular Localization
- Cytoplasm, Cytoskeleton, Nucleus
- Post Translation Modifications
- Ubiquitination at Lys62, Lys90, Lys98, and Lys159 (NX_Q9Y3A5 [NX_Q9Y3A5-1])
Modification sites at PhosphoSitePlus (Q9Y3A5)
Glycosylation from GlyGen (Q9Y3A5) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_057122.2
- Function
- Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3176 | Hi-Affi™ Recombinant Rabbit Anti-SBDS Monoclonal Antibody (DS3176AB) | WB, ICC, IP | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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