Provided is an antibody (clone CT240) which binds and neutralizes PAI-1 by converting PAI-1 to its latent form or increasing proteolytic cleavage. The antibody csn be used for the detection, diagnosis or treatment studies of a disease or condition associated with PAI-1 or a combination thereof.
Figure 1 Anti-PAI-1 antibody CT140 was found to neutralize uPA to an extent similar the murine monoclonal antibody 33B8.
Figure 2 Binding of CT140 to human PAI-1 was determined by P-ELISA.
Figure 3 Binding of CT140 to mouse PAI-1 was determined by P-ELISA.
Figure 4 CT140 is therapeutic in a UUO animal model at days 1, 9 and 14 of treatment.
CL=contralateral kidney control. In each comparison shown, PBS control animal response is shown on the left and CT140 treated animals are shown on the right.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
DrMAB-1148 | Recombinant Human Anti-Human SERPINE1 Antibody scFv Fragment, clone 1040-1F6 | ELISA, WB, ICH, IP | scFv |
DrMAB-1151 | Recombinant Human Anti-Human SERPINE1 Antibody scFv Fragment, clone 1040-1F6 [HRP] | ELISA, WB, ICH, IP | scFv |
HPAB-0269-FY-S(P) | Human Anti-SERPINE1 Recombinant Antibody (clone PICK167-A01-fgl); scFv Fragment | FuncS, Inhib | Human scFv |
HPAB-AP787-YC-S(P) | Human Anti-SERPINE1 Recombinant Antibody (clone CT240); scFv Fragment | ELISA, Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0923CL | Human Anti-SERPINE1 Recombinant Antibody (TAB-0923CL) | ELISA | Human IgG |
TAB-0929CL | Human Anti-SERPINE1 Recombinant Antibody (TAB-0929CL) | ELISA | Human antibody |
TAB-0923CL-S(P) | Human Anti-SERPINE1 Recombinant Antibody; scFv Fragment (TAB-0923CL-S(P)) | ELISA | Human scFv |
TAB-0929CL-S(P) | Human Anti-SERPINE1 Recombinant Antibody; scFv Fragment (TAB-0929CL-S(P)) | ELISA | Human scFv |
TAB-0929CL-F(E) | Human Anti-SERPINE1 Recombinant Antibody; Fab Fragment (TAB-0929CL-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0924CL | Mouse Anti-SERPINE1 Recombinant Antibody (TAB-0924CL) | ELISA | Mouse IgG1 |
TAB-0924CL-S(P) | Mouse Anti-SERPINE1 Recombinant Antibody; scFv Fragment (TAB-0924CL-S(P)) | ELISA | Mouse scFv |
TAB-0924CL-F(E) | Mouse Anti-SERPINE1 Recombinant Antibody; Fab Fragment (TAB-0924CL-F(E)) | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0925CL | Human Anti-SERPINE1 Recombinant Antibody (TAB-0925CL) | ELISA | Humanized IgG |
TAB-0926CL | Anti-Human SERPINE1 Recombinant Antibody (CT110) | Immunohistochemical staining, WB, ELISA | Humanized antibody |
TAB-0927CL | Anti-Human SERPINE1 Recombinant Antibody (CT140) | Immunohistochemical staining, WB, ELISA | Humanized antibody |
TAB-0928CL | Anti-Human SERPINE1 Recombinant Antibody (55F4C12) | Immunohistochemical staining, WB, ELISA | Humanized antibody |
TAB-0925CL-F(E) | Human Anti-SERPINE1 Recombinant Antibody; Fab Fragment (TAB-0925CL-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1525CT | Recombinant Mouse anti-Human SERPINE1 Monoclonal antibody (4B230) | WB | |
ZG-0077U | Rabbit Anti-SERPINE1 Recombinant Antibody (clone 10C3) | ELISA, WB, IHC | Rabbit IgG |
VS3-QX1004 | Mouse Anti-SERPINE1 Recombinant Antibody (clone 1D5) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
VS3-WK183 | Mouse Anti-SERPINE1 Recombinant Antibody (clone H9-D5) | WB, ELISA | Mouse IgG1 |
VS3-FY1328 | Recombinant Rabbit Anti-SERPINE1 Antibody (clone R05-6J6) | WB, ICC, IF, IP | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1944CQ | Recombinant Mouse Anti-SERPINE1 Antibody (124K1) | ELISA, Neut, WB | IgG1, κ |
NEUT-1945CQ | Recombinant Mouse Anti-SERPINE1 Antibody (12V3) | Neut, WB | IgG1 |
NEUT-1946CQ | Recombinant Mouse Anti-SERPINE1 Antibody (33B8) | ELISA, Neut, WB | IgG1, κ |
NEUT-1947CQ | Recombinant Mouse Anti-SERPINE1 Antibody (33H1F7) | ELISA, IHC-P, Neut, WB | IgG1 |
NEUT-1948CQ | Recombinant Mouse Anti-SERPINE1 Antibody (CBL946) | ELISA, IHC, Neut, WB | IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-3223 | Hi-Affi™ Recombinant Rabbit Anti-SERPINE1 Monoclonal Antibody (DS3223AB) | WB, IP | IgG |
MOR-4719 | Hi-Affi™ Recombinant Rabbit Anti-SERPINE1 Monoclonal Antibody (TH233DS) | WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0269-FY-F(E) | Human Anti-SERPINE1 Recombinant Antibody (clone PICK167-A01-fgl); Fab Fragment | FuncS, Inhib | Human Fab, κ |
HPAB-AP787-YC-F(E) | Human Anti-SERPINE1 Recombinant Antibody (clone CT240); Fab Fragment | ELISA, Neut | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABJ-0054 | Camelid Anti-SERPINE1 Recombinant Antibody (PABJ-0054) | ELISA, Inhib | Camelid VHH |
PABJ-0055 | Camelid Anti-SERPINE1 Recombinant Antibody (PABJ-0055) | ELISA, Inhib | Camelid VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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