Human Anti-SERPINE1 Recombinant Antibody (clone CT240) (CAT#: HPAB-AP787-YC)
Provided is an antibody (clone CT240) which binds and neutralizes PAI-1 by converting PAI-1 to its latent form or increasing proteolytic cleavage. The antibody csn be used for the detection, diagnosis or treatment studies of a disease or condition associated with PAI-1 or a combination thereof.
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Custom Production
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Neut
Figure 1 Anti-PAI-1 antibody CT140 was found to neutralize uPA to an extent similar the murine monoclonal antibody 33B8.
ELISA
Figure 2 Binding of CT140 to human PAI-1 was determined by P-ELISA.
ELISA
Figure 3 Binding of CT140 to mouse PAI-1 was determined by P-ELISA.
FuncS
Figure 4 CT140 is therapeutic in a UUO animal model at days 1, 9 and 14 of treatment.
CL=contralateral kidney control. In each comparison shown, PBS control animal response is shown on the left and CT140 treated animals are shown on the right.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized IgG, κ
- Specificity
- Human SERPINE1
- Species Reactivity
- Human
- Clone
- CT240
- Applications
- ELISA, Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Neutralization, Enzyme-Linked Immunosorbent Assay and Functional Assay.
Target
- Alternative Names
- Serpin Family E Member 1; Serine (Or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1; Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1; Endothelial Plasminogen Activator Inhibitor; Serpin E1; PLANH1
- Gene ID
- 5054
- UniProt ID
- P05121
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1148 | Recombinant Human Anti-Human SERPINE1 Antibody scFv Fragment, clone 1040-1F6 | ELISA, WB, ICH, IP | scFv |
| DrMAB-1151 | Recombinant Human Anti-Human SERPINE1 Antibody scFv Fragment, clone 1040-1F6 [HRP] | ELISA, WB, ICH, IP | scFv |
| HPAB-0269-FY-S(P) | Human Anti-SERPINE1 Recombinant Antibody (clone PICK167-A01-fgl); scFv Fragment | FuncS, Inhib | Human scFv |
| HPAB-AP787-YC-S(P) | Human Anti-SERPINE1 Recombinant Antibody (clone CT240); scFv Fragment | ELISA, Neut | Human scFv |
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For Research Use Only. Not For Clinical Use.
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