Anti-Human SERPINE1 Recombinant Antibody (CT140) (CAT#: TAB-0927CL)
CT140 is a humanized version of murine monoclonal antibody 33B8 variable heavy chain fused to an IgG4 Fc construct. The binding of CT140 to rat, mouse, rabbit and human PAI-1 was determined by P-ELISA. CT140 specifically bound human and rabbit PAI-1 to a greater extent than murine and rat PAI-1. This humanized anti-PAI-1 antibody (CT140) can bind and neutralize PAI-1 by converting PAI-1 to its latent form or increasing proteolytic cleavage. It is shown to protect mice from liver fibrosis, indicating that it decreases the population of myofibroblasts, the most prominent population of matrix producing cells.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50039/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50039/if_selected.jpg
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows moderate cytoplasmic and secreted positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68501/ihc_selected.jpg
(Immunohistochemical staining of human placenta shows moderate cytoplasmic and secreted positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68501/ihc_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50039/850_C6_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50039/850_C6_1_blue_red_green.jpg
Figure 4 RNA cell line category: Cell line enhanced (BJ, HUVEC TERT2, LHCN-M2, TIME, U-138 MG, U-251 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106366-SERPINE1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106366-SERPINE1
Figure 4 RNA cell line category: Cell line enhanced (BJ, HUVEC TERT2, LHCN-M2, TIME, U-138 MG, U-251 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106366-SERPINE1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106366-SERPINE1
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- CT140
- Applications
- Immunohistochemical staining, WB, ELISA
- Related Disease
- Liver fibrosis
Target
- Alternative Names
- SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; PAI; PAI1; PAI-1; PLANH1; plasminogen activator inhibitor 1; serpin E1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
- Gene ID
- 5054
- UniProt ID
- A0A024QYT5
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Single Domain Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1148 | Recombinant Human Anti-Human SERPINE1 Antibody scFv Fragment, clone 1040-1F6 | ELISA, WB, ICH, IP | scFv |
| DrMAB-1151 | Recombinant Human Anti-Human SERPINE1 Antibody scFv Fragment, clone 1040-1F6 [HRP] | ELISA, WB, ICH, IP | scFv |
| HPAB-0269-FY-S(P) | Human Anti-SERPINE1 Recombinant Antibody (clone PICK167-A01-fgl); scFv Fragment | FuncS, Inhib | Human scFv |
| HPAB-AP787-YC-S(P) | Human Anti-SERPINE1 Recombinant Antibody (clone CT240); scFv Fragment | ELISA, Neut | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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