Rabbit Anti-SFRP1 Recombinant Antibody (clone R06-4C7) (CAT#: VS3-XY3503)
It is a recombinant rabbit antibody targeting the SFRP1 (Secreted frizzled related protein 1), which inhibits tubule formation and bud growth in metanephroi in kidney development. This antibody recognizes and binds to human SFRP1. It has been determined using Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry or Immunofluorescence.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SK-MEL-30
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoli.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64870/1262_E9_7_selected.jpg
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoli.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64870/1262_E9_7_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8116/20024_B_7_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8116/20024_B_7_5.jpg
Figure 3 Salivary gland
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8116/20024_B_1_1.jpg
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8116/20024_B_1_1.jpg
Figure 4 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8116/19883_A_7_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8116/19883_A_7_3.jpg
Figure 5 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8116/19883_A_7_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8116/19883_A_7_4.jpg
Figure 6 Testis
(Elongated or late spermatids Staining: Low Intensity: Weak Quantity:>75% Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Round or early spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8116/19883_A_6_6.jpg
(Elongated or late spermatids Staining: Low Intensity: Weak Quantity:>75% Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Round or early spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8116/19883_A_6_6.jpg
Figure 7 RNA cell line category: Cell line enriched (hTERT-RPE1)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104332-SFRP1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104332-SFRP1
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human SFRP1
- Species Reactivity
- Human
- Clone
- R06-4C7
- Applications
- WB, IHC-P, ICC, IF
- Related Disease
- Osteoporosis; Hepatocellular Carcinoma
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
Target
- Alternative Names
- FRP; FRP1; FrzA; FRP-1; SARP2
- Gene ID
- 6422
- UniProt ID
- Q8N474
- Long Name
- Secreted frizzled related protein 1
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn173 (NX_Q8N474 [NX_Q8N474-1])
Modification sites at PhosphoSitePlus (Q8N474)
Glycosylation from GlyGen (Q8N474) 5 sites, 3 O-linked glycans (4 sites)
- Protein Refseq
- NP_003003.3
- Function
- Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts.
They have a role in regulating cell growth and differentiation in specific cell types.
SFRP1 decreases intracellular beta-catenin levels (By similarity).
Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2533z | Mouse Anti-SFRP1 Recombinant Antibody (clone 28B5) | WB, ICC, IHC, IP | Mouse IgG2a, κ |
| MRO-1385-CN | Recombinant Rabbit Anti-SFRP1 Monoclonal Antibody (JA11-68) | WB | Rabbit IgG |
| MRO-2183-CN | Rabbit Anti-SFRP1 Polyclonal Antibody (MRO-2183-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-WK233 | Rabbit Anti-SFRP1 Recombinant Antibody (clone JA11-68) | WB | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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