Mouse Anti-SGK3 Recombinant Antibody (clone 2506W45) (CAT#: VS-0625-FY77)

• Immunogen
• Antibody raised against human SGK3, targeting amino acids 67-145 near the N-terminus.

• Host Species
• Mouse

• Type
• Mouse IgG2b, kappa

• Species Reactivity
• Human, Mouse, Rat

• Clone
• 2506W45

• Applications
• Western Blot, Immunoprecipitation, Immunofluorescence, Immunohistochemistry-Paraffin, ELISA

• Related Disease
• Immunodeficiency 55 and Hypophosphatemic Rickets

• Purification
• Purified with Protein A or G affinity chromatography

• Purity
• >90% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Optimal dilutions for assays should be determined by the user.

• Alternative Names
• Serum/Glucocorticoid Regulated Kinase Family Member 3; Cytokine-Independent Survival Kinase; EC 2.7.11.1; SGKL; CISK; Serum/Glucocorticoid Regulated Kinase Family, Member 3; Serum/Glucocorticoid Regulated Kinase-Like

• Gene ID
• 23678

• UniProt ID
• Q96BR1

• Long Name
• Serum/Glucocorticoid Regulated Kinase Family Member 3

• Sequence Similarities
• Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

• Cellular Localization
• Cytoplasmic vesicle {ECO:0000250}
  Early endosome
  Recycling endosome

• Post Translation Modifications
• Activated by phosphorylation on Ser-486 by an unknown kinase, transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-320.
  Modification sites at PhosphoSitePlus
  Modification sites at neXtProt

• Protein Refseq
• NP_001028750.1; NP_037389.4; NP_733827.2

• Function
• Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration.
  Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.

Secondary Antibody

• 2ND-049CQ
• Goat Anti-Mouse IgG2b Antibody, R-PE

• 2RD-A1466-YJ
• Goat Anti-Mouse IgG2b Secondary antibody

• 2RD-A1560-YJ
• Rabbit Anti-Mouse IgG2b Secondary antibody (Clone RM108)

Isotype Control

• MOB-203CQ
• Mouse IgG2b, kappa Isotype Control Antibody

• MOB-212YJL
• Mouse IgG2b kappa Isotype Control Antibody (Mopc21)

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