Anti-SKP2 (clone W24V200) Recombinant Antibody Coupled Liposome (VS-1024-FY199)
CAT#: VS-1024-FY199
This innovative type of liposome is designed to be conjugated with anti-SKP2 antibodies, specifically targeting the overexpressed SKP2 protein that is implicated in the survival and proliferation of melanoma cells. By leveraging the unique properties of these liposomes, the treatment not only aims to increase the selectivity and affinity of therapeutic agents directly to cancer cells but also enhances the overall efficacy of the treatment regimen. Ultimately, this targeted approach is expected to minimize unwanted side effects, providing a more focused and effective therapeutic option for patients suffering from melanoma.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm, nucleoli & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/51196/if_selected.jpg
Normal Tissue
Figure 2 Colon
Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13491/144767_A_9_3.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13491/144767_A_4_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (BEWO, RH-30)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145604-SKP2
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More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- W24V200
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This recombinant mouse monoclonal antibody has been developed with the specific intent to bind to the SKP2 protein, which is essential in the regulation of the cell cycle. With its ability to identify and quantify SKP2 levels, this antibody serves as a powerful tool in research aimed at understanding cellular proliferation and tumorigenesis.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- SKP2
- Introduction
- This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms.
- Alternative Names
- S-Phase Kinase Associated Protein 2; S-Phase Kinase-Associated Protein 2, E3 Ubiquitin Protein Ligase; F-Box/LRR-Repeat Protein 1; P45skp2; FBXL1; S-Phase Kinase-Associated Protein 2 (P45); CDK2/Cyclin A-Associated Protein P45
- Full Name
- S-Phase Kinase Associated Protein 2
- Gene ID
- 6502
- UniProt ID
- Q13309
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome.
Deubiquitinated by USP13.
- Protein Refseq
- XP_054209162.1
- Function
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription.
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Datasheet
MSDS
COA
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See other products for "SKP2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1784MZ | Recombinant Mouse Anti-Human SKP2 Antibody (clone nBcdbn79998) | WB | Mouse antibody |
| ZG-091R | Mouse Anti-SKP2 Recombinant Antibody (ZG-091R) | WB, ELISA | Mouse IgG |
| ZG-0562U | Rabbit Anti-SKP2 Recombinant Antibody (clone 3C11) | ELISA, IF, FC | Rabbit IgG |
| VS3-FY1343 | Recombinant Rabbit Anti-SKP2 Antibody (clone R08-0A2) | WB, ICC, IF | Rabbit IgG |
| VS7-0425-WR868 | Mouse Anti-SKP2 Monoclonal Antibody (clone 6G9D10) | WB, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3275 | Hi-Affi™ Recombinant Rabbit Anti-SKP2 Monoclonal Antibody (DS3275AB) | WB, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY483 | Mouse Anti-NHP SKP2 Recombinant Antibody (clone SKP2-8D9) | WB, IF, IP, ELISA | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2080 | Anti-SKP2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6616 | Anti-Human SKP2 Immunohistochemistry Kit | IHC |
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