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SKP2
Loading...Anti-SKP2 Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Cdc53 scaffold protein anti-Human SKP2 (SCC-L251)
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- Scaffold Name: Cdc53
- Target: SKP2
- Species Reactivity: Human
- Derivation: Phage display
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- Mouse Anti-NHP SKP2 Recombinant Antibody (clone SKP2-8D9) (VS-1024-XY483)
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- Species Reactivity: Human, Non-human primate
- Type: Mouse IgG1, kappa
- Application: WB, IF, IP, ELISA
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- Mouse Anti-SKP2 Monoclonal Antibody (clone 6G9D10) (VS7-0425-WR868)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA
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- Anti-SKP2 Immunohistochemistry Kit (VS-0325-XY2080)
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- Species Reactivity: Human, Mouse, Rat
- Target: SKP2
- Application: IHC
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- Anti-Human SKP2 Immunohistochemistry Kit (VS-0525-XY6616)
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- Species Reactivity: Human
- Target: SKP2
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms.
Protein class
Cancer-related genes
Predicted location
Intracellular
Single cell type specificity
Group enriched (Extravillous trophoblasts, Cytotrophoblasts, Syncytiotrophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (BEWO, RH-30)
Interaction
Part of a SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with CKS1. Interacts with ASB2 which is the substrate-recognition component of a probable ECS E3 ubiquitin-protein ligase complex; ASB2 is likely to bridge the formation of dimeric E3-ubiquitin-protein ligase complexes composed of an ECS complex and an SCF(SKP2) complex (PubMed:21119685). Interacts with the cyclin-A-CDK2 complex. Interacts with ORC1, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1, UBP43, MYC, TOB1, TAL1 and KMT2A/MLL1. Interacts with TRIM21. Interacts with cyclin-E (By similarity). Interacts with IFI27; promotes the ubiquitin-mediated proteasomal degradation of hepatitis C virus/HCV non-structural protein NS5A (PubMed:27194766). Interacts with CARM1 (By similarity). (Microbial infection) Interacts with hepatitis C virus/HCV non-structural protein NS5A; promotes the ubiquitin-mediated proteasomal degradation of NS5A.
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