Rabbit Anti-SORT1 Recombinant Antibody (clone R08-6G5)
CAT#: VS3-XY3511
It is a recombinant rabbit antibody specific for SORT1 (Sortilin 1), which functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. The antibody specifically reacts with human, mouse and rat SORT1. This product has been reported for use in Western Blot and Immunohistochemistry-Paraffin. The recommended dilutions of Western Blot and Immunohistochemistry-Paraffin is 1/500-1/1000 and 1/50-1/100.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11498/if_selected.jpg
Normal Tissue
Figure 3 Hippocampal formation
High expression in hippocampal formation
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_B_8_6_val_selected.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_6_6.jpg
Normal Tissue
Figure 5 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_8_8.jpg
Normal Tissue
Figure 6 Hippocampus
Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_B_8_6.jpg
Normal Tissue
Figure 7 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_7_3.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134243-SORT1
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat SORT1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R08-6G5
- Applications
- WB, IHC-P
- Related Disease
- Low Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6; Myocardial Infarction
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
Target
- Alternative Names
- NT3; Gp95; NTR3; LDLCQ6
- Gene ID
- 6272
- UniProt ID
- Q99523
- Long Name
- Sortilin 1
- Cellular Localization
- Golgi apparatus, Endosome membrane
- Post Translation Modifications
- The N-terminal propeptide is cleaved by furin and possibly other homologous proteases. (Q99523-SORT_HUMAN)
Palmitoylated (PubMed:18817523).
Undergoes cysteine S-palmitoylation which promotes the partitioning of the receptor into an endosomal membrane subdomain where it can interact with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus.
- Protein Refseq
- XP_005271158.1; XP_005271157.1
- Function
- Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface.
Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR).
Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "SORT1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1383LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1383LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| HPAB-1384LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1384LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| HPAB-1385LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1385LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| HPAB-1386LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1386LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| HPAB-1387LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1387LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1378LY | Human Anti-SORT1 Recombinant Antibody (HPAB-1378LY) | Inhib, FC, ELISA | Humanized IgG |
| HPAB-1379LY | Human Anti-SORT1 Recombinant Antibody (HPAB-1379LY) | Inhib, FC, ELISA | Humanized IgG |
| HPAB-1380LY | Human Anti-SORT1 Recombinant Antibody (HPAB-1380LY) | Inhib, FC, ELISA | Humanized IgG |
| HPAB-1381LY | Human Anti-SORT1 Recombinant Antibody (HPAB-1381LY) | Inhib, FC, ELISA | Humanized IgG |
| HPAB-1382LY | Human Anti-SORT1 Recombinant Antibody (HPAB-1382LY) | Inhib, FC, ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1378LY-F(E) | Human Anti-SORT1 Recombinant Antibody; Fab Fragment (HPAB-1378LY-F(E)) | Inhib, FC, ELISA | Humanized Fab |
| HPAB-1379LY-F(E) | Human Anti-SORT1 Recombinant Antibody; Fab Fragment (HPAB-1379LY-F(E)) | Inhib, FC, ELISA | Humanized Fab |
| HPAB-1380LY-F(E) | Human Anti-SORT1 Recombinant Antibody; Fab Fragment (HPAB-1380LY-F(E)) | Inhib, FC, ELISA | Humanized Fab |
| HPAB-1381LY-F(E) | Human Anti-SORT1 Recombinant Antibody; Fab Fragment (HPAB-1381LY-F(E)) | Inhib, FC, ELISA | Humanized Fab |
| HPAB-1382LY-F(E) | Human Anti-SORT1 Recombinant Antibody; Fab Fragment (HPAB-1382LY-F(E)) | Inhib, FC, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2146 | Anti-SORT1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6811 | Anti-Mouse SORT1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6810 | Anti-Human SORT1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6812 | Anti-Rat SORT1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC454 | Recombinant Anti-SORT1 Vesicular Antibody, EV Displayed (VS-0425-YC454) | Block, ELISA, FC, Cell-uptake |
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