Rabbit Anti-SORT1 Recombinant Antibody (clone R08-6G5) (CAT#: VS3-XY3511)
It is a recombinant rabbit antibody specific for SORT1 (Sortilin 1), which functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. The antibody specifically reacts with human, mouse and rat SORT1. This product has been reported for use in Western Blot and Immunohistochemistry-Paraffin. The recommended dilutions of Western Blot and Immunohistochemistry-Paraffin is 1/500-1/1000 and 1/50-1/100.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/if_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11498/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11498/if_selected.jpg
Figure 3 Hippocampal formation
(High expression in hippocampal formation)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_B_8_6_val_selected.jpg
(High expression in hippocampal formation)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_B_8_6_val_selected.jpg
Figure 4 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_6_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_6_6.jpg
Figure 5 Lymph node
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_8_8.jpg
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_8_8.jpg
Figure 6 Hippocampus
(Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_B_8_6.jpg
(Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_B_8_6.jpg
Figure 7 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_7_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_7_3.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134243-SORT1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134243-SORT1
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat SORT1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R08-6G5
- Applications
- WB, IHC-P
- Related Disease
- Low Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6; Myocardial Infarction
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
Target
- Alternative Names
- NT3; Gp95; NTR3; LDLCQ6
- Gene ID
- 6272
- UniProt ID
- Q99523
- Long Name
- Sortilin 1
- Cellular Localization
- Golgi apparatus, Endosome membrane
- Post Translation Modifications
- The N-terminal propeptide is cleaved by furin and possibly other homologous proteases. (Q99523-SORT_HUMAN)
Palmitoylated (PubMed:18817523).
Undergoes cysteine S-palmitoylation which promotes the partitioning of the receptor into an endosomal membrane subdomain where it can interact with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus.
- Protein Refseq
- XP_005271158.1; XP_005271157.1
- Function
- Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface.
Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR).
Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1383LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1383LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| HPAB-1384LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1384LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| HPAB-1385LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1385LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| HPAB-1386LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1386LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| HPAB-1387LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1387LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
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