Mouse Anti-SOX11 Recombinant Antibody (VS3-FY2878)
CAT#: VS3-FY2878
The anti-SOX11 is an impressive mouse recombinant monoclonal antibody that specifically reacts with human SOX11 protein, a calculated molecular weight of the protein is about 46.7 kDa. The optimal dilution for this antibody is Western Blot (1/500-1/2000), Immunohistochemistry (1/50-1/200), Flow cytometry (1/50-1/200) and ELISA (1/1000-1/10000).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/448/1836_H7_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human caudate
Immunohistochemical staining of human caudate shows nuclear positivity in glial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/536/1419_B_9_7_selected.jpg
Normal Tissue
Figure 3 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows moderate nuclear positivity in subsets of cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56152/121445_A_4_2_selected.jpg
Normal Tissue
Figure 4 IHC staining of human colon
Immunohistochemical staining of human colon shows nuclear positivity in subsets of glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56153/121440_A_8_3_selected.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56152/121445_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56152/121445_A_5_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (AF22, NTERA-2, REH, RH-30, SCLC-21H, SH-SY5Y)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000176887-SOX11
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human SOX11
- Species Reactivity
- Human
- Applications
- Western Blot, Immunohistochemistry, Flow cytometry, ELISA
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 46.7 kDa.
- Related Disease
- Intellectual Developmental Disorder With Microcephaly And With Or Without Ocular Malformations Or Hypogonadotropic Hypogonadism and Coffin-Siris Syndrome 1
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Immunohistochemistry: 1/50-1/200
Flow cytometry: 1/50-1/200
ELISA: 1/1000-1/10000
Target
- Alternative Names
- SRY-Box 11; SRY-Related HMG-Box Gene 11; SRY (Sex Determining Region Y)-Box 11; SRY (Sex-Determining Region Y)-Box 11; Transcription Factor SOX-11; SRY Box 11; MRD27
- Gene ID
- 6664
- UniProt ID
- P35716
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (P35716)
Modification sites at neXtProt (NX_P35716)
Glycosylation from GlyGen (P35716) 1 site, 1 O-linked glycan (1 site)
- Function
- Transcription factor that acts as a transcriptional activator (PubMed:24886874, 26543203).
Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity).
Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity).
Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "SOX11"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2048z | Mouse Anti-SOX11 Recombinant Antibody (clone 33G1) | WB, IHC | Mouse IgG2a |
| MRO-1425-CN | Recombinant Rabbit Anti-SOX11 Monoclonal Antibody (CBACN-522) | WB, IF, IP | Rabbit IgG |
| VS3-CJ908 | Rabbit Anti-SOX11 Recombinant Antibody (VS3-CJ908) | WB, ICC, IF, IP | Rabbit IgG |
| VS7-0425-WR910 | Mouse Anti-SOX11 Recombinant Antibody (clone 1A6C10) | FC | Mouse IgG2b |
| VS7-0425-WR911 | Mouse Anti-SOX11 Recombinant Antibody (clone 8D5D4) | WB, IHC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3375 | Hi-Affi™ Recombinant Rabbit Anti-SOX11 Monoclonal Antibody (DS3375AB) | WB, IP | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6817 | Anti-SOX11 Immunohistochemistry Kit | IHC |
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