Mouse Anti-SOX11 Recombinant Antibody (VS3-FY2878) (CAT#: VS3-FY2878)
The anti-SOX11 is an impressive mouse recombinant monoclonal antibody that specifically reacts with human SOX11 protein, a calculated molecular weight of the protein is about 46.7 kDa. The optimal dilution for this antibody is Western Blot (1/500-1/2000), Immunohistochemistry (1/50-1/200), Flow cytometry (1/50-1/200) and ELISA (1/1000-1/10000).
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/448/1836_H7_1_selected.jpg
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/448/1836_H7_1_selected.jpg
Figure 2 IHC staining of human caudate
(Immunohistochemical staining of human caudate shows nuclear positivity in glial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/536/1419_B_9_7_selected.jpg
(Immunohistochemical staining of human caudate shows nuclear positivity in glial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/536/1419_B_9_7_selected.jpg
Figure 3 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows moderate nuclear positivity in subsets of cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56152/121445_A_4_2_selected.jpg
(Immunohistochemical staining of human small intestine shows moderate nuclear positivity in subsets of cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56152/121445_A_4_2_selected.jpg
Figure 4 IHC staining of human colon
(Immunohistochemical staining of human colon shows nuclear positivity in subsets of glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56153/121440_A_8_3_selected.jpg
(Immunohistochemical staining of human colon shows nuclear positivity in subsets of glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56153/121440_A_8_3_selected.jpg
Figure 5 Kidney
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56152/121445_A_8_5.jpg
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56152/121445_A_8_5.jpg
Figure 6 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56152/121445_A_5_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56152/121445_A_5_6.jpg
Figure 7 RNA cell line category: Cell line enhanced (AF22, NTERA-2, REH, RH-30, SCLC-21H, SH-SY5Y)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000176887-SOX11
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000176887-SOX11
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human SOX11
- Species Reactivity
- Human
- Applications
- Western Blot, Immunohistochemistry, Flow cytometry, ELISA
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 46.7 kDa.
- Related Disease
- Intellectual Developmental Disorder With Microcephaly And With Or Without Ocular Malformations Or Hypogonadotropic Hypogonadism and Coffin-Siris Syndrome 1
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Immunohistochemistry: 1/50-1/200
Flow cytometry: 1/50-1/200
ELISA: 1/1000-1/10000
Target
- Alternative Names
- SRY-Box 11; SRY-Related HMG-Box Gene 11; SRY (Sex Determining Region Y)-Box 11; SRY (Sex-Determining Region Y)-Box 11; Transcription Factor SOX-11; SRY Box 11; MRD27
- Gene ID
- 6664
- UniProt ID
- P35716
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (P35716)
Modification sites at neXtProt (NX_P35716)
Glycosylation from GlyGen (P35716) 1 site, 1 O-linked glycan (1 site)
- Function
- Transcription factor that acts as a transcriptional activator (PubMed:24886874, 26543203).
Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity).
Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity).
Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity).
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2048z | Mouse Anti-SOX11 Recombinant Antibody (clone 33G1) | WB, IHC | Mouse IgG2a |
| MRO-1425-CN | Recombinant Rabbit Anti-SOX11 Monoclonal Antibody (CBACN-522) | WB, IF, IP | Rabbit IgG |
| VS13-YC1095 | Rabbit Anti-SOX11 Recombinant Antibody (VS13-YC1095) | WB, ICC, IF, IP | Rabbit IgG |
| VS7-0425-WR910 | Mouse Anti-SOX11 Recombinant Antibody (clone 1A6C10) | FC | Mouse IgG2b |
| VS7-0425-WR911 | Mouse Anti-SOX11 Recombinant Antibody (clone 8D5D4) | WB, IHC, FC | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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