Mouse Anti-SRP14 Recombinant Antibody (clone 2506W49) (CAT#: VS-0625-FY88)
The Mouse IgG3 kappa monoclonal antibody, clone 2506W49, broadly targets SRP14 in Human, Mouse, and Rat. Its immunogen is a recombinant Rat SRP14 fusion protein, with an epitope mapping to amino acids 35-73. With an approximate antigen size of 45 kDa, this antibody is suitable for Western Blot, Immunoprecipitation, Immunofluorescence, and ELISA, providing versatile detection capabilities for SRP14.
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG3, kappa
- Specificity
- Specific for an epitope mapping to amino acids 35-73, located within an internal region of human SRP14.
- Species Reactivity
- Human, Mouse, Rat
- Clone
- 2506W49
- Applications
- Western Blot, Immunoprecipitation, Immunofluorescence, ELISA
Product Property
- Purification
- Purified with Protein A or G affinity chromatography
- Purity
- >90% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Optimal dilutions for assays should be determined by the user.
Target
- Alternative Names
- Signal Recognition Particle 14; Homologous Alu RNA Binding Protein; 18 KDa Alu RNA-Binding Protein; Signal Recognition Particle 14kD (Homologous Alu RNA-Binding Protein); Signal Recognition Particle 14 KDa Protein; ALURBP
- Gene ID
- 6727
- UniProt ID
- P37108
- Long Name
- Signal Recognition Particle 14
- Sequence Similarities
- Belongs to the SRP14 family.
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- Ubiquitination at Lys43, Lys55, Lys74, and Lys78
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites, 1 O-linked glycan
- Protein Refseq
- NP_001296363.1; NP_003125.3
- Function
- Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:11089964).
SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (PubMed:11089964).
The complex of SRP9 and SRP14 is required for SRP RNA binding.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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