Mouse Anti-SRPK2 Recombinant Antibody (clone 2506W52) (CAT#: VS-0625-FY89)

• Host Species
• Mouse

• Type
• Mouse IgG1

• Species Reactivity
• Human

• Clone
• 2506W52

• Applications
• Western Blot, Immunofluorescence

• Related Disease
• Autism Spectrum Disorder and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7

• Purification
• Purified with Protein A or G affinity chromatography

• Purity
• >90% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• BSA, glycerol

• Preservative
• Less than 0.09% sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Optimal dilutions for assays should be determined by the user.

• Alternative Names
• SRSF Protein Kinase 2; SFRS Protein Kinase 2; Serine/Arginine-Rich Protein-Specific Kinase 2; Serine/Arginine-Rich Splicing Factor Kinase 2; SR-Protein-Specific Kinase 2; SR Protein Kinase 2

• Gene ID
• 6733

• UniProt ID
• P78362

• Long Name
• SRSF Protein Kinase 2

• Sequence Similarities
• Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.

• Cellular Localization
• Cytoplasm {ECO:0000269 PubMed:21056976, 21157427, 28076779, 9472028}
  Nucleus, nucleoplasm {ECO:0000269 PubMed:21157427, 28076779, 9472028}
  Nucleus speckle {ECO:0000269 PubMed:28076779, 9472028}
  Chromosome

• Post Translation Modifications
• Phosphorylation at Thr-492 by PKB/AKT1 enhances its stimulatory activity in triggering cyclin-D1 expression and promoting apoptosis in neurons, which can be blocked by YWHAB.
  It also enhances its protein kinase activity toward ACIN1 and SRSF2, promotes its nuclear translocation and prevents its proteolytic cleavage.

• Protein Refseq
• XP_006716161.1; XP_011514838.1; XP_011514840.1; XP_016868050.2; XP_024302661.1

• Function
• Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, 21056976, 9472028).
  Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491).
  This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression.

Secondary Antibody

• 2ND-047CQ
• Goat Anti-Mouse IgG1 Antibody, R-PE

• 2RD-A1460-YJ
• Goat Anti-Mouse IgG1 Secondary antibody

Isotype Control

• MOB-065CQ
• Mouse IgG1 Isotype Control Antibody

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