Mouse Anti-SRPK2 Recombinant Antibody (clone 2506W52)
CAT#: VS-0625-FY89
This Mouse IgG1 monoclonal antibody, clone 2506W52, specifically targets human SRPK2. Its immunogen is a recombinant Rat SRPK2 fusion protein, with an epitope mapping to amino acids 363-485. With an approximate antigen size of 45 kDa, this antibody is suitable for Western Blot and Immunofluorescence, providing reliable detection for SRPK2.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Species Reactivity
- Human
- Clone
- 2506W52
- Applications
- Western Blot, Immunofluorescence
- Related Disease
- Autism Spectrum Disorder and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7
Product Property
- Purification
- Purified with Protein A or G affinity chromatography
- Purity
- >90% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- BSA, glycerol
- Preservative
- Less than 0.09% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Optimal dilutions for assays should be determined by the user.
Target
- Alternative Names
- SRSF Protein Kinase 2; SFRS Protein Kinase 2; Serine/Arginine-Rich Protein-Specific Kinase 2; Serine/Arginine-Rich Splicing Factor Kinase 2; SR-Protein-Specific Kinase 2; SR Protein Kinase 2
- Gene ID
- 6733
- UniProt ID
- P78362
- Long Name
- SRSF Protein Kinase 2
- Sequence Similarities
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
- Cellular Localization
- Cytoplasm {ECO:0000269 PubMed:21056976, 21157427, 28076779, 9472028}
Nucleus, nucleoplasm {ECO:0000269 PubMed:21157427, 28076779, 9472028}
Nucleus speckle {ECO:0000269 PubMed:28076779, 9472028}
Chromosome
- Post Translation Modifications
- Phosphorylation at Thr-492 by PKB/AKT1 enhances its stimulatory activity in triggering cyclin-D1 expression and promoting apoptosis in neurons, which can be blocked by YWHAB.
It also enhances its protein kinase activity toward ACIN1 and SRSF2, promotes its nuclear translocation and prevents its proteolytic cleavage.
- Protein Refseq
- XP_006716161.1; XP_011514838.1; XP_011514840.1; XP_016868050.2; XP_024302661.1
- Function
- Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, 21056976, 9472028).
Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491).
This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0625-FY89. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "SRPK2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2176 | Anti-SRPK2 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, IHC, FC, Cyt, ELISA
Application: ELISA, Inhib, FuncS
Application: ELISA, FC, IF, IHC, WB
Application: ELISA, FC, Neut, Inhib
Application: Neut, FuncS, IHC, ELISA, FC, Inhib
Application: Inhib, FC, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
