Rabbit Anti-TBXA2R Recombinant Antibody (clone R68-6F-6) (CAT#: VS3-FY2173)
Clone R68-6F-6 is a rabbit IgG recombinant monoclonal antibody that is specifically engineered to target human TBXA2R protein, a calculated weight of 37 kDa. It cross-reacts with mouse, rat.
The following recommendations serve as a starting point for assay optimization. The actual working concentration may vary and should be determined by the user. The R68-6F-6 is recommended for detection of target protein by western blotting (dilution range 1:500-1:1000).
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to nuclear speckles & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77366/1760_B11_17_cr594b79e2452cd_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to nuclear speckles & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77366/1760_B11_17_cr594b79e2452cd_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (HeLa, U-2197, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000006638-TBXA2R
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000006638-TBXA2R
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat TBXA2R
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R68-6F-6
- Applications
- Western Blot
- Conjugate
- Unconjugated
- MW
- The calculated weight of the target protein is approximately 37 kDa, while the observed molecular weight stands at 50kDa.
- Related Disease
- Bleeding Disorder, Platelet-Type, 13 and Phenytoin Allergy
Product Property
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.4), 150 mM NaCl, 50% glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Thromboxane A2 Receptor; Prostanoid TP Receptor; TXA2-R; BDPLT13
- Gene ID
- 6915
- UniProt ID
- P21731
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn4 and Asn16 (NX_P21731 [NX_P21731-3])
Modification sites at PhosphoSitePlus (P21731)
Glycosylation from GlyGen (P21731) 2 sites
- Protein Refseq
- XP_011526516.1; XP_054177825.1; NP_001051.1; NP_963998.2
- Function
- Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2443z | Mouse Anti-TBXA2R Recombinant Antibody (MOB-2443z) | WB, IP, IF, ELISA | Mouse IgG3, κ |
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