Rabbit Anti-TFAP2A Recombinant Antibody (clone R07-7E5) (CAT#: VS3-FY1651)

• Immunogen
• Synthetic peptide of human AP2 alpha

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Rat TFAP2A

• Species Reactivity
• Human, Rat

• Clone
• R07-7E5

• Applications
• Western Blot, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 48 kDa, while the observed molecular weight stands at 48 kDa.

• Related Disease
• Branchiooculofacial Syndrome and Amblyopia

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunoprecipitation: 1/20

• Alternative Names
• Transcription Factor AP-2 Alpha; Transcription Factor AP-2 Alpha (Activating Enhancer Binding Protein 2 Alpha); Activating Enhancer-Binding Protein 2-Alpha; AP-2 Transcription Factor; Activator Protein 2; AP2-ALPHA; AP2TF

• Gene ID
• 7020

• UniProt ID
• P05549

• Sequence Similarities
• Belongs to the AP-2 family.

• Cellular Localization
• Nucleus

• Post Translation Modifications
• Sumoylated on Lys-10; which inhibits transcriptional activity.

• Protein Refseq
• NP_001027451.1; NP_001035890.1; NP_001358995.1

• Function
• Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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