Mouse Anti-TIA1 Recombinant Antibody (VS3-FY2894)
CAT#: VS3-FY2894
The anti-TIA1 product is a recombinant mouse monoclonal antibody that binds to human TIA1 protein, a calculated molecular weight of the protein is about 43 kDa. The antibody can be utilized for detection of TIA1 by Immunohistochemistry (1/50-1/200) and Immunocytochemistry (1/50-1/200), Flow cytometry (1/50-1/200) and ELISA (1/1000-1/10000).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56961/973_E5_2_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000116001-TIA1
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human TIA1
- Species Reactivity
- Human
- Applications
- Immunohistochemistry, Immunocytochemistry, Flow cytometry, ELISA
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 43 kDa.
- Related Disease
- Welander Distal Myopathy and Amyotrophic Lateral Sclerosis 26 With Or Without Frontotemporal Dementia
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry: 1/50-1/200
Immunocytochemistry: 1/50-1/200
Flow cytometry: 1/50-1/200
ELISA: 1/1000-1/10000
Target
- Alternative Names
- TIA1 Cytotoxic Granule Associated RNA Binding Protein; T-Cell-Restricted Intracellular Antigen-1; Nucleolysin TIA-1 Isoform P40; TIA-1; TIA1 Cytotoxic Granule-Associated RNA-Binding Protein; P40-TIA-1 (Containing P15-TIA-1)
- Gene ID
- 7072
- UniProt ID
- P31483
- Cellular Localization
- Nucleus
Cytoplasm
Cytoplasm, Stress granule
- Post Translation Modifications
- Phosphorylated by FASTK; phosphorylation occurs after FAS ligation in FAS-mediated apoptosis and before DNA fragmentation. (P31483-TIA1_HUMAN)
Modification sites at PhosphoSitePlus (P31483)
Modification sites at neXtProt (NX_P31483)
Glycosylation from GlyGen (P31483) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_047301581.1; XP_047301582.1; XP_047301583.1; XP_047301584.1
- Function
- Acts as a modulator of alternative splicing for the apoptotic FAS receptor, thereby promoting apoptosis (PubMed:11106748, 1934064, 17488725).
Binds to the 5' splice site region of FAS intron 5 to promote accumulation of transcripts that include exon 6 at the expense of transcripts in which exon 6 is skipped, thereby leading to the transcription of a membrane-bound apoptotic FAS receptor, which promotes apoptosis.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "TIA1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2446z | Mouse Anti-TIA1 Recombinant Antibody (clone 44A7) | WB, FC, ICC, IF | Mouse IgG2b |
| MRO-1494-CN | Rabbit Anti-TIA1 Recombinant Antibody (clone JM42-11) | WB, IF, IHC, IP | Rabbit IgG |
| VS13-YC1158 | Rabbit Anti-TIA1 Recombinant Antibody (VS13-YC1158) | IHC-P | Rabbit IgG |
| VS7-0425-WR985 | Mouse Anti-TIA1 Recombinant Antibody (clone 2A10B12) | FC | Mouse IgG1 |
| VS7-0425-WR986 | Mouse Anti-TIA1 Recombinant Antibody (clone 3A3B9) | IHC, ICC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3569 | Rabbit Anti-TIA1 Recombinant Antibody (clone DS3569AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2289 | Anti-TIA1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7251 | Anti-Human TIA1 Immunohistochemistry Kit | IHC |
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