Mouse Anti-TIA1 Recombinant Antibody (VS3-FY2894) (CAT#: VS3-FY2894)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human TIA1

• Species Reactivity
• Human

• Applications
• Immunohistochemistry, Immunocytochemistry, Flow cytometry, ELISA

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 43 kDa.

• Related Disease
• Welander Distal Myopathy and Amyotrophic Lateral Sclerosis 26 With Or Without Frontotemporal Dementia

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Immunohistochemistry: 1/50-1/200
  Immunocytochemistry: 1/50-1/200
  Flow cytometry: 1/50-1/200
  ELISA: 1/1000-1/10000

• Alternative Names
• TIA1 Cytotoxic Granule Associated RNA Binding Protein; T-Cell-Restricted Intracellular Antigen-1; Nucleolysin TIA-1 Isoform P40; TIA-1; TIA1 Cytotoxic Granule-Associated RNA-Binding Protein; P40-TIA-1 (Containing P15-TIA-1)

• Gene ID
• 7072

• UniProt ID
• P31483

• Cellular Localization
• Nucleus
  Cytoplasm
  Cytoplasm, Stress granule

• Post Translation Modifications
• Phosphorylated by FASTK; phosphorylation occurs after FAS ligation in FAS-mediated apoptosis and before DNA fragmentation. (P31483-TIA1_HUMAN)
  Modification sites at PhosphoSitePlus (P31483)
  Modification sites at neXtProt (NX_P31483)
  Glycosylation from GlyGen (P31483) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_047301581.1; XP_047301582.1; XP_047301583.1; XP_047301584.1

• Function
• Acts as a modulator of alternative splicing for the apoptotic FAS receptor, thereby promoting apoptosis (PubMed:11106748, 1934064, 17488725).
  Binds to the 5' splice site region of FAS intron 5 to promote accumulation of transcripts that include exon 6 at the expense of transcripts in which exon 6 is skipped, thereby leading to the transcription of a membrane-bound apoptotic FAS receptor, which promotes apoptosis.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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