AibGenesis™ Rabbit Anti-TIRAP Recombinant Antibody (AibG-Rb-TI795)
CAT#: VS-0426-FY795
Developed by an AI-powered antibody discovery platform, this TIRAP antibody aids susceptibility research, providing specific signals in Western Blotting.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SiHa
Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm, cytosol & cytokinetic bridge.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54431/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human gallbladder
Immunohistochemical staining of human gallbladder shows cytoplasmic and membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54431/123965_A_4_4_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54431/123965_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54431/123965_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54431/123965_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54431/123965_A_4_6.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000150455-TIRAP
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Specifications
- Immunogen
- Human
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human TIRAP
- Species Reactivity
- Human, Mouse, Rat
- Clone
- AibG-Rb-TI795
- Applications
- Western Blot
- Conjugate
- Unconjugated, Biotin and FITC are available.
- Related Disease
- Malarial Susceptibility
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- PBS, 0.05% Protective protein, 50% Glycerol
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (1:1000-1:2000)
Target
- Alternative Names
- MAL; Wyatt; TIRAP
- UniProt ID
- P58753
- Long Name
- TIR Domain Containing Adaptor Protein
- Cellular Localization
- Cytoplasm, Cell membrane, Membrane
- Post Translation Modifications
- Phosphorylated by IRAK1 and IRAK4.
Also phosphorylated by BTK.
Polyubiquitinated.
Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation.
Modification sites at PhosphoSitePlus (P58753)
Modification sites at neXtProt (NX_P58753)
Glycosylation from GlyGen (P58753) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001034750.1; NP_001305705.1; NP_001305706.1; NP_683708.1
- Function
- Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "TIRAP"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3596z | Mouse Anti-TIRAP Recombinant Antibody (clone 32D10) | WB, IP, IF, ELISA | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2335MZ | Recombinant Mouse Anti-Human TIRAP Antibody (clone 30E2066) | WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3577 | Rabbit Anti-TIRAP Recombinant Antibody (clone DS3577AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7283 | Anti-TIRAP Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS14-YC589 | AibGenesis™ Rabbit Anti-TIRAP Recombinant Antibody (AibG-Rb-IR385) | WB | Rabbit IgG |
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