This product is a recombinant human antibody that recognizes Trastuzumab. The antibody was purified by affinity chromatography. It can be used in Block.
Figure 1 ELISA of pooledsera from mice (n= 20/group) immunized with scFv40, scFv69 or HER2-Fc.
Values are presented as mean ± SD of the Absorbance at 490 nm from three independent experiments.
Ladjemi, M. Z., Chardes, T., Corgnac, S., Garambois, V., Morisseau, S., Robert, B., ... & Pelegrin, A. (2011). Vaccination with human anti-trastuzumab anti-idiotype scFv reverses HER2 immunological tolerance and induces tumor immunity in MMTV. f. huHER2 (Fo5) mice. Breast Cancer Research, 13(1), R17.
Figure 2 Flow cytometry analysis in HER2-overexpressing SK-OV-3 of the HER2-specific response of pooled sera from mice immunized with PBS, anti-Id scFv40, scFv69 or with HER2-Fc.
Sera were recovered at Day 42 post-vaccination. Antibody binding was detected using a FITC-labeled goat anti-mouse antibody. FITC-labeled secondary antibody alone was used asa negative control to determine the level of background fluorescence.
Ladjemi, M. Z., Chardes, T., Corgnac, S., Garambois, V., Morisseau, S., Robert, B., ... & Pelegrin, A. (2011). Vaccination with human anti-trastuzumab anti-idiotype scFv reverses HER2 immunological tolerance and induces tumor immunity in MMTV. f. huHER2 (Fo5) mice. Breast Cancer Research, 13(1), R17.
Figure 3 Inhibition of cell viability and analysis of SK-OV-3 tumor progression in nude mice.
Inhibition of cell viability in SK-OV-3 Luccells following treatment with sera from BALB/c mice immunized with PBS (NoMS), scFv40 (scFv40MS), scFv69 (scFv69MS) or with HER2-Fc(HER2-FcMS). Cell number was proportional to the emitted luminescence and results were normalized to the fluorescence of untreated cells. Grey boxes represent the 25th and 75th percentiles with the medians as black lines; whiskers mark the smallest and largest non-outlier observations, and outliers are indicated by dots.
Ladjemi, M. Z., Chardes, T., Corgnac, S., Garambois, V., Morisseau, S., Robert, B., ... & Pelegrin, A. (2011). Vaccination with human anti-trastuzumab anti-idiotype scFv reverses HER2 immunological tolerance and induces tumor immunity in MMTV. f. huHER2 (Fo5) mice. Breast Cancer Research, 13(1), R17.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1002 | Recombinant Anti-Trastuzumab Antibody | ELISA, WB, FC, FuncS | IgG |
MHH-1002 | Recombinant Human Anti-Trastuzumab Antibody | WB, IP, FuncS | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1002-F(E) | Recombinant Anti-Trastuzumab Antibody Fab Fragment | IP, RIA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1002-S(P) | Recombinant Anti-Trastuzumab Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
MHH-1002-S(P) | Recombinant Human Anti-Trastuzumab Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
ABA-079WJ | Rabbit Anti-Trastuzumab Antibody, Alexa Fluor® 405 | FC | Rabbit IgG |
ABA-080WJ | Rabbit Anti-Trastuzumab Antibody, Alexa Fluor® 488 | FC | Rabbit IgG |
ABA-081WJ | Rabbit Anti-Trastuzumab Antibody, Alexa Fluor® 594 | FC | Rabbit IgG |
ABA-082WJ | Rabbit Anti-Trastuzumab Antibody, Alexa Fluor® 647 | FC | Rabbit IgG |
FAMAB-1416CQ | Human Anti-Trastuzumab Recombinant Antibody (clone scFv69) | ELISA, FC, Inhib, FuncS | Human IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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