Rabbit Anti-TRPM7 Recombinant Antibody (clone R03-8E5) (CAT#: VS3-XY3531)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat TRPM7

• Species Reactivity
• Human, Mouse, Rat

• Clone
• R03-8E5

• Applications
• WB, ICC, IF, FC

• Related Disease
• Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1; Hypomagnesemia 1, Intestinal

• Clonality
• Monoclonal

• Aggregation
• < 5%

• Format
• Liquid

• Buffer
• PBS (pH 7.4), 150 mM NaCl and 50% glycerol

• Preservative
• 0.02% sodium azide

• Storage
• Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• WB: 1/500-1/1000
  IF: 1/50-1/200
  FC: 1/50-1/100

• Alternative Names
• ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK

• Gene ID
• 54822

• UniProt ID
• Q96QT4

• Long Name
• Transient receptor potential cation channel subfamily M member 7

• Cellular Localization
• Membrane

• Post Translation Modifications
• Autophosphorylated. (Q96QT4-TRPM7_HUMAN)
  Modification sites at PhosphoSitePlus (Q96QT4)
  Modification sites at neXtProt (NX_Q96QT4)

• Protein Refseq
• NP_060142.3

• Function
• Essential ion channel and serine/threonine-protein kinase.
  Divalent cation channel permeable to calcium and magnesium (PubMed:35561741).
  Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death.
  Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Secondary Antibody

• 2RD-A1473-YJ
• Goat Anti-Rabbit IgG-F(ab')2 Secondary antibody

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