Rabbit Anti-TRPM7 Recombinant Antibody (clone R03-8E5) (CAT#: VS3-XY3531)
It is a recombinant rabbit antibody targeting the TRPM7 (Transient receptor potential cation channel subfamily M member 7), which has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. This antibody recognizes and binds to human, mouse and rat TRPM7. It has been determined using Western Blot, Flow cytometry, Immunocytochemistry or Immunofluorescence.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35522/1070_F1_3_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35522/1070_F1_3_selected.jpg
Figure 2 High expression in parathyroid gland
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52173/164812_A_2_8.jpg
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52173/164812_A_2_8.jpg
Figure 3 Colon
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52173/164812_A_7_3.jpg
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52173/164812_A_7_3.jpg
Figure 4 Kidney
(Distal tubules Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52173/164812_A_8_5.jpg
(Distal tubules Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52173/164812_A_8_5.jpg
Figure 5 RNA cell line category: Cell line enhanced (U-2197)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000092439-TRPM7
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000092439-TRPM7
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat TRPM7
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R03-8E5
- Applications
- WB, ICC, IF, FC
- Related Disease
- Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1; Hypomagnesemia 1, Intestinal
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IF: 1/50-1/200
FC: 1/50-1/100
Target
- Alternative Names
- ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK
- Gene ID
- 54822
- UniProt ID
- Q96QT4
- Long Name
- Transient receptor potential cation channel subfamily M member 7
- Cellular Localization
- Membrane
- Post Translation Modifications
- Autophosphorylated. (Q96QT4-TRPM7_HUMAN)
Modification sites at PhosphoSitePlus (Q96QT4)
Modification sites at neXtProt (NX_Q96QT4)
- Protein Refseq
- NP_060142.3
- Function
- Essential ion channel and serine/threonine-protein kinase.
Divalent cation channel permeable to calcium and magnesium (PubMed:35561741).
Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death.
Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2352CT | Recombinant Mouse anti-Human TRPM7 Monoclonal antibody (QSNU4) | WB, ICC/IF |
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