Rabbit Anti-UIMC1 Recombinant Antibody (clone R01-0D5) (CAT#: VS3-FY2076)
The R01-0D5 recombinant monoclonal antibody demonstrates high specificity in target human UIMC1. It is suitable for use in a variety of assays, including WB, IHC-F, IHC-P, ICC/IF. The antibody has the positive detection of RAP80 by immunocytochemistry analysis of RAP80 (green) in Hela and western blot analysis of RAP80 in Hela, A549, HL-60, U2OS lysates.
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ICC
Figure 1 Anti-UIMC1 Antibody (VS3-FY2076) in ICC.
Immunocytochemistry staining of RAP80 (green) in Hela using the anti-RAP80 antibody. Nuclear DNA was labeled with DAPI (shown in blue).
WB
Figure 2 Anti-UIMC1 Antibody (VS3-FY2076) in WB.
The RAP80 expression in Hela, A549, HL-60, U2OS lysates were detected using the anti-RAP80 by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human RAP80
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human UIMC1
- Species Reactivity
- Human
- Clone
- R01-0D5
- Applications
- Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence
- MW
- The calculated weight of the target protein is approximately 80 kDa, while the observed molecular weight stands at 80 kDa.
- Related Disease
- Cancer
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunofluorescence: 1/50-1/200
Target
- Alternative Names
- Ubiquitin Interaction Motif Containing 1; Retinoid X Receptor-Interacting Protein 110; Receptor-Associated Protein 80; RAP80; Ubiquitin Interaction Motif-Containing Protein 1; Receptor Associated Protein 80; BRCA1-A Complex Subunit RAP80; X2HRIP110; RXRIP110
- Gene ID
- 51720
- UniProt ID
- Q96RL1
- Sequence Similarities
- Belongs to the RAP80 family.
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Sumoylated. (Q96RL1-UIMC1_HUMAN)
Phosphorylated upon DNA damage by ATM or ATR. (Q96RL1-UIMC1_HUMAN)
Ubiquitination at Lys20, Lys31, Lys146, Lys75, Lys90, Lys232, Lys245, Lys544, Lys567, Lys587, Lys607, Lys635, Lys374, and Lys382 (NX_Q96RL1 [NX_Q96RL1-1])
Modification sites at PhosphoSitePlus (Q96RL1)
- Protein Refseq
- XP_005265987.1; XP_005265989.1; XP_005265990.1; XP_006714934.1; XP_011532872.1
- Function
- Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3785 | Rabbit Anti-UIMC1 Recombinant Antibody (clone DS3785AB) | WB, IHC, ICC | Rabbit IgG |
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