Rabbit Anti-UPP1 Recombinant Antibody (clone R16-9Z-4) (CAT#: VS3-FY2143)
Clone R16-9Z-4 is a rabbit recombinant antibody that has been meticulously crafted to specifically bind to human UPP1 protein, a calculated weight of 34 kDa. It cross-reacts with mouse, rat.
The following recommendations serve as a starting point for assay optimization. The actual working concentration may vary and should be determined by the user. The R16-9Z-4 is recommended for detection of target protein by western blotting (dilution range 1:500-1:1000).
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54040/981_B3_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54040/981_B3_1_selected.jpg
Figure 2 High expression in esophagus
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55394/127294_B_5_1_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55394/127294_B_5_1_selected.jpg
Figure 3 Low expression in stomach 1
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55394/127294_A_5_1_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55394/127294_A_5_1_val_selected.jpg
Figure 4 Small intestine
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55394/127294_A_6_2.jpg
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55394/127294_A_6_2.jpg
Figure 5 RNA cell line category: Cell line enriched (hTERT-HME1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000183696-UPP1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000183696-UPP1
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat UPP1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R16-9Z-4
- Applications
- Western Blot
- Conjugate
- Unconjugated
- MW
- The calculated weight of the target protein is approximately 34kDa, while the observed molecular weight stands at 28kDa.
- Related Disease
- Gastric Cancer and Colorectal Cancer
Product Property
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.4), 150 mM NaCl, 50% glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Uridine Phosphorylase 1; UrdPase 1; UPase 1; UP; Uridine Phosphorylase; EC 2.4.2.3; UDRPASE; UPASE; UPP
- Gene ID
- 7378
- UniProt ID
- Q16831
- Sequence Similarities
- Belongs to the PNP/UDP phosphorylase family.
- Cellular Localization
- cytosol, nucleoplasm
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (Q16831)
Modification sites at neXtProt (NX_Q16831)
Glycosylation from GlyGen (Q16831) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011513814.1; XP_011513815.1; XP_011513816.1; XP_047276753.1; XP_047276754.1
- Function
- Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds (Probable).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0618MZ | Chicken Anti-UPP1 (ab1) Polyclonal IgY | WB | Chicken antibody |
| BRD-0619MZ | Chicken Anti-UPP1 (ab2) Polyclonal IgY | WB | Chicken antibody |
| BRD-0942MZ | Chicken Anti-UPP1 Polyclonal IgY | WB | Chicken antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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