Rabbit Anti-VDR Recombinant Antibody (clone R04-9B1) (CAT#: VS3-XY3538)
This antibody is a recombinant rabbit antibody targeting the VDR (Vitamin D receptor), which plays a central role in calcium homeostasis. VDR also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites. The antibody specifically reacts with human, mouse and rat VDR. It has been reported for use in Western Blot and Immunoprecipitation. The recommended dilutions of Western Blot is 1/500-1/1000.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47740/if_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47740/if_selected.jpg
Figure 2 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72102/1802_G2_7_selected.jpg
(Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72102/1802_G2_7_selected.jpg
Figure 3 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4617/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4617/if_selected.jpg
Figure 4 RNA cell line category: Cell line enhanced (HBEC3-KT, HDLM-2, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000111424-VDR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000111424-VDR
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat VDR
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R04-9B1
- Applications
- WB, IP
- Related Disease
- Vitamin D-Dependent Rickets, Type 2A; Rickets
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
Target
- Alternative Names
- NR1I1; PPP1R163
- Gene ID
- 7421
- UniProt ID
- P11473
- Long Name
- Vitamin D receptor
- Cellular Localization
- Nucleus, Cytoplasm
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (P11473)
Modification sites at neXtProt (NX_P11473)
Glycosylation from GlyGen (P11473) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_047285456.1
- Function
- Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:28698609, 16913708, 15728261, 10678179).
Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609).
The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609).
Plays a central role in calcium homeostasis.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1719z | Mouse Anti-VDR Recombinant Antibody (clone 37C12) | WB, ELISA, IHC, IP | Mouse IgG2a |
| MOB-2221CT | Recombinant Mouse anti-Human VDR Monoclonal antibody (9A7) | ICC/IF, WB | |
| MRO-1588-CN | Rabbit Anti-VDR Recombinant Antibody (clone JA11-16) | WB, IHC, FC | Rabbit IgG |
| HPAB-1108-CN | Mouse Anti-VDR Recombinant Antibody (HPAB-1108-CN) | ELISA | Mouse IgG |
| ZG-0021U | Rabbit Anti-VDR Recombinant Antibody (clone 3C7) | ELISA, WB, IHC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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