Anti-Vdr Intrabody [Tat] (IAB-B056(T))

Recombinant anti-Vdr intrabody in fusion with HIV Tat works within cells to down regulate the mouse Vdr, expressed in CHO cells.bindThe vitamin D receptor related disorders including skin disorders, immune system disorders, and proliferative disorders.      

mouse vitamin D receptor
Cell Penetrating Peptide
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
Species Reactivity
Can be useful in applications such as: Fluorescence-activated cell sorting; Immunocytochemistry; Functional studies
Alternative Names
125 dihydroxyvitamin D3 receptor; 125 dihydroxyvitamin D3 receptor; 25-dihydroxyvitamin D3 receptor; Member 1; NR1I1; Nuclear receptor subfamily 1 group I member 1; PPP1R163; Protein phosphatase 1, regulatory subunit 163
Entrez Gene ID

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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