Recombinant Anti-mouse Vdr Intrabody [Tat] (CAT#: IAB-B056(T))
Recombinant anti-Vdr intrabody in fusion with HIV Tat works within cells to down regulate the mouse Vdr, expressed in CHO cells.bindThe vitamin D receptor related disorders including skin disorders, immune system disorders, and proliferative disorders.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47740/if_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47740/if_selected.jpg
Figure 2 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72102/1802_G2_7_selected.jpg
(Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72102/1802_G2_7_selected.jpg
Figure 3 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4617/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4617/if_selected.jpg
Figure 4 RNA cell line category: Cell line enhanced (HBEC3-KT, HDLM-2, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000111424-VDR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000111424-VDR
Specifications
- Immunogen
- mouse vitamin D receptor
- Host Species
- mouse
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- mouse
- Applications
- Can be useful in applications such as: Fluorescence-activated cell sorting; Immunocytochemistry; Functional studies
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Target
- Alternative Names
- 125 dihydroxyvitamin D3 receptor; 125 dihydroxyvitamin D3 receptor; 25-dihydroxyvitamin D3 receptor; Member 1; NR1I1; Nuclear receptor subfamily 1 group I member 1; PPP1R163; Protein phosphatase 1, regulatory subunit 163; VDR; VDR_HUMAN; Vitamin D (1,25-d
- Gene ID
- 22337
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1719z | Mouse Anti-VDR Recombinant Antibody (clone 37C12) | WB, ELISA, IHC, IP | Mouse IgG2a |
| MOB-2221CT | Recombinant Mouse anti-Human VDR Monoclonal antibody (9A7) | ICC/IF, WB | |
| MRO-1588-CN | Rabbit Anti-VDR Recombinant Antibody (clone JA11-16) | WB, IHC, FC | Rabbit IgG |
| HPAB-1108-CN | Mouse Anti-VDR Recombinant Antibody (HPAB-1108-CN) | ELISA | Mouse IgG |
| ZG-0021U | Rabbit Anti-VDR Recombinant Antibody (clone 3C7) | ELISA, WB, IHC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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