Mouse Anti-XIAP Recombinant Antibody (VS3-FY2920) (CAT#: VS3-FY2920)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human, Mouse and Rat XIAP

• Species Reactivity
• Human, Mouse, Rat

• Applications
• Western Blot, Immunohistochemistry, Immunocytochemistry

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 56.7 kDa.

• Related Disease
• Lymphoproliferative Syndrome, X-Linked, 2 and Lymphoproliferative Syndrome 2

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/2000
  Immunohistochemistry: 1/50-1/200
  Immunocytochemistry: 1/10-1/25

• Gene ID
• 331

• UniProt ID
• P98170

• Sequence Similarities
• Belongs to the IAP family.

• Cellular Localization
• Cytoplasm
  Nucleus

• Post Translation Modifications
• S-Nitrosylation down-regulates its E3 ubiquitin-protein ligase activity. (P98170-XIAP_HUMAN)
  Autoubiquitinated. (P98170-XIAP_HUMAN)
  Ubiquitination at Lys10, Lys31, Lys116, Lys168, Lys208, Lys322, Lys328, and Lys358 (NX_P98170 [NX_P98170-1])
  Modification sites at PhosphoSitePlus (P98170)
  Glycosylation from GlyGen (P98170) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• NP_001191330.1; NP_001365519.1; NP_001365520.1; NP_001365521.1

• Function
• Acts as a direct caspase inhibitor (PubMed:11257230, 11257231, 12620238).
  Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry (PubMed:11257230, 11257231, 16352606, 16916640).
  Inactivates CASP9 by keeping it in a monomeric, inactive state (PubMed:12620238).
  Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS, PTEN and BIRC5/survivin (PubMed:17967870, 19473982, 20154138, 22103349, 22607974, 30026309, 29452636, 17560374).
  Acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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