This product is a recombinant Human antibody that can recognize ZIKV ED3. Z021, a potent neutralizer that recognizes an epitope on the lateral ridge of the envelope domain III (EDIII) of ZIKV and is protective against ZIKV in mice. Z021 binds to the EDIII of both ZIKV and DENV1.
Figure 1 Graphs show neutralization of ZIKV luciferase RVPs by Z021 and Z004 using wild-type RVPs.
Data are presented as mean±SD of triplicates, and a representative of two experiments is plotted. Values are relative to no antibody control.
Keeffe, J. R., Van Rompay, K. K., Olsen, P. C., Wang, Q., Gazumyan, A., Azzopardi, S. A., ... & Watanabe, J. (2018). A combination of two human monoclonal antibodies prevents Zika virus escape mutations in non-human primates. Cell reports, 25(6), 1385-1394.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
PABC-440 | Recombinant Human Anti-ZIKV ED3 Antibody (Z004) | ELISA, Neut | Human IgG1 |
PABC-441 | Recombinant Human Anti-ZIKV ED3 Antibody (Z006) | ELISA, Neut | Human IgG1 |
PABC-465 | Recombinant Human Anti-ZIKV ED3 Antibody (Z23) | ELISA, BL | Human IgG1, κ |
PABC-496 | Recombinant Human Anti-ZIKV ED3 Antibody (ZKA190) | Neut, FuncS, ELISA | Human IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBC-405 | Recombinant Human Anti-ZIKV ED3 Antibody Fab Fragment (Z021) | ELISA, Neut | Human Fab |
PFBC-440 | Recombinant Human Anti-ZIKV ED3 Antibody Fab Fragment (Z004) | ELISA, Neut | Human Fab |
PFBC-441 | Recombinant Human Anti-ZIKV ED3 Antibody Fab Fragment (Z006) | ELISA, Neut | Human Fab |
PFBC-465 | Recombinant Human Anti-ZIKV ED3 Antibody Fab Fragment (Z23) | ELISA, BL | Human Fab |
PFBC-496 | Recombinant Human Anti-ZIKV ED3 Antibody Fab Fragment (ZKA190) | ELISA, Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBC-405 | Recombinant Human Anti-ZIKV ED3 Antibody scFv Fragment (Z021) | ELISA, Neut | Human scFv |
PSBC-440 | Recombinant Human Anti-ZIKV ED3 Antibody scFv Fragment (Z004) | ELISA, Neut | Human scFv |
PSBC-441 | Recombinant Human Anti-ZIKV ED3 Antibody scFv Fragment (Z006) | ELISA, Neut | Human scFv |
PSBC-465 | Recombinant Human Anti-ZIKV ED3 Antibody scFv Fragment (Z23) | ELISA, BL | Human scFv |
PSBC-496 | Recombinant Human Anti-ZIKV ED3 Antibody scFv Fragment (ZKA190) | ELISA, Neut | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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