DRB1*04:01/Human gp100 (IYRRRLMKQDFSVPQLPHS) MHC Tetramer (CAT#: MHC-YF854)

• Allele
• DRB1*04:01

• Class
• Class II

• MHC Species
• Human

• Antigen
• gp100

• Antigen Species
• Human

• Peptide
• IYRRRLMKQDFSVPQLPHS

• Range
• 615-633

• Application
• FCM

• Antigen Introduction
• This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.

• Alternative Names
• P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E

• Gene ID
• 6490

• UniProt ID
• P40967

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